Varma M P, Adgey A A, Connolly J H
Br Heart J. 1980 Jun;43(6):695-9. doi: 10.1136/hrt.43.6.695.
Eight patients with chronic Q fever endocarditis were treated with tetracycline for up to 40 months. In addition, five of these patients received co-trimoxazole. Six patients had prosthetic valves. Two patients who had Q fever endocarditis on their native valves required valve replacement because of haemodynamic difficulties: in only one did the Q fever endocarditis contribute to the haemodynamic difficulty. One patient died. It is suggested that medical treatment is continued until clinically and haematologically there is no evidence of endocarditis and the Q fever phase 1 antibody titre is less than 200. No recurrence of Q fever endocarditis has been detected in three of our patients who have now stopped treatment.
8例慢性Q热心内膜炎患者接受了长达40个月的四环素治疗。此外，其中5例患者还接受了复方新诺明治疗。6例患者有人工瓣膜。2例自体瓣膜发生Q热心内膜炎的患者因血流动力学困难需要进行瓣膜置换：其中只有1例Q热心内膜炎导致了血流动力学困难。1例患者死亡。建议持续进行药物治疗，直至临床和血液学检查均无心内膜炎证据且Q热1期抗体滴度低于200。在我们现已停止治疗的3例患者中，未检测到Q热心内膜炎复发。
