Blekkenhorst G H, Harrison G G, Cook E S, Eales L
Br J Anaesth. 1980 Aug;52(8):759-62. doi: 10.1093/bja/52.8.759.
The activity of delta-aminolaevulinic acid synthetase (E.C. 2.3.1.37) (ALA-S) was measured in rat liver after the simultaneous administration of various anesthetic agents and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in vivo. Flunitrazepam, Althesin and phenobarbitone caused a significant increase in the activity of the enzyme which was not observed with propanidid, etomidate and minaxolone. It is suggested that DDC-treated rat, which resembles latent human variegate porphyria, may be a more valid method of testing drugs for their ability to elicit acute porphyric phases in susceptible individuals. The anaesthetic agents which induced the activity of hepatic ALA-S in this model are not recommended in patients with genetic hepatic porphyria.
在大鼠体内同时给予各种麻醉剂和3,5-二乙氧羰基-1,4-二氢可力丁（DDC）后，测定大鼠肝脏中δ-氨基乙酰丙酸合成酶（E.C. 2.3.1.37）（ALA-S）的活性。氟硝西泮、阿法沙龙和苯巴比妥可使该酶的活性显著增加，而丙泮尼地、依托咪酯和米那索龙则未观察到这种情况。有人提出，经DDC处理的大鼠类似于潜在的人类杂合性卟啉症，可能是一种更有效的方法，用于测试药物在易感个体中引发急性卟啉症阶段的能力。在该模型中诱导肝脏ALA-S活性的麻醉剂不推荐用于遗传性肝卟啉症患者。
