Noble A D, Letchworth A T
Br J Obstet Gynaecol. 1980 Aug;87(8):726-8. doi: 10.1111/j.1471-0528.1980.tb04607.x.
Fifty patients with endometriosis were treated with hormones: 27 with danazol and 23 with Enavid (mestranol 75 micrograms and norethynodrel 5 mg). Side effects were more common and potentially more serious in the group treated with Enavid. Fewer women completed treatment with Enavid and their physical signs showed little improvement. Danazol was better tolerated and the results of treatment, as judged by improvement of symptoms or signs and in future fertility rates, were superior to those recorded in the Enavid treated group. Patients with large endometriotic cysts or severe fibrosis did not benefit from medical treatment. Danazol treatment appeared helpful for women who had mild or moderate endometriotic disease. It may be used alone or as a complimentary treatment after conservative surgical operations.
27名使用达那唑，23名使用炔雌醇甲醚（炔雌醇75微克和异炔诺酮5毫克）。在使用炔雌醇甲醚治疗的组中，副作用更常见且可能更严重。完成炔雌醇甲醚治疗的女性较少，且她们的体征改善甚微。达那唑的耐受性更好，从症状或体征的改善以及未来生育率判断，治疗效果优于炔雌醇甲醚治疗组。患有大的子宫内膜异位囊肿或严重纤维化的患者未从药物治疗中获益。达那唑治疗似乎对患有轻度或中度子宫内膜异位症的女性有帮助。它可单独使用或在保守性手术后作为辅助治疗。
