[米斯克洛龙（氯贝丁酯）对大鼠二甲基肼诱导肠道肿瘤的影响]
[Effect of miskleron (clofibrate) on dimethylhydrazine induction of intestinal tumors in rats].
作者信息
Bershteĭn L M, Pozharisskiĭ K M, Dil'man V M
出版信息
Biull Eksp Biol Med. 1980 Sep;90(9):350-2.
PMID:7426739
Abstract
Intestinal tumors were induced in male rats by dimethylhydrazine (14 mg/kg body weight subcutaneously once a week during 20 weeks). Part of animals received clofibrat per os in a dose of 25 mg a day 5 times a week. Clofibrat did not influence the frequency of the development of intestinal tumors but significantly decreased the number of medium-size and large tumors. The possible mechanisms of clofibrat action as well as the use of clofibrat and some related agents in oncology are discussed.
摘要
用二甲基肼（每周皮下注射14毫克/千克体重，持续20周）诱导雄性大鼠发生肠道肿瘤。部分动物每周5次口服氯贝丁酯，剂量为每天25毫克。氯贝丁酯不影响肠道肿瘤的发生频率，但显著减少了中大型肿瘤的数量。本文讨论了氯贝丁酯作用的可能机制以及氯贝丁酯和一些相关药物在肿瘤学中的应用。
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[Effect of miskleron (clofibrate) on dimethylhydrazine induction of intestinal tumors in rats].[米斯克洛龙（氯贝丁酯）对大鼠二甲基肼诱导肠道肿瘤的影响]
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