Pollard M, Luckert P H
J Natl Cancer Inst. 1983 Jun;70(6):1103-5.
Intestinal tumors were induced in randomly propagated Lobund Sprague-Dawley rats by dimethylhydrazine dihydrochloride and by methylazoxymethanol acetate. At 14, 63, and 77 days after exposure to a carcinogen, rats were fed, ad libitum, indomethacin in the drinking water (20 mg/liter) for 20 and 40 weeks. The development of intestinal tumors was prevented or retarded significantly compared to that of control animals. Among control rats at 20, 40, and 52 weeks, the numbers of tumors per rat were relatively constant, but the individual tumors were increased in size.
通过二盐酸二甲肼和乙酸甲基氧化偶氮甲醇在随机繁殖的洛邦德·斯普拉格-道利大鼠中诱发肠道肿瘤。在接触致癌物后的第14、63和77天，大鼠自由饮用含吲哚美辛（20毫克/升）的水，持续20周和40周。与对照动物相比，肠道肿瘤的发生明显受到预防或延缓。在20周、40周和52周的对照大鼠中，每只大鼠的肿瘤数量相对恒定，但单个肿瘤的大小有所增加。
