近交系小鼠急性镉中毒：品系差异研究

Acute cadmium intoxication in inbred mice: a study on strain differences.

作者信息

Hata A, Tsunoo H, Nakajima H, Shintaku K, Kimura M

出版信息

Chem Biol Interact. 1980 Oct;32(1-2):29-39. doi: 10.1016/0009-2797(80)90066-6.

Abstract

Male C3H, BALB/c and DBA/2 mice were injected subcutaneously with a single dose of 30 mumol CdCl2/kg. Most of the C3H mice died within 15 h, while all of DBA/2 survived for at least 48 h. At 6 h after Cd-injection, histology revealed severe hemorrhage, fatty change, zonal hepatocyte necrosis and congestion of C3H livers, while these findings were rare in the other strains even at 48 h post-injection. The rate of metallothionein (MT) induction at 6 h was significantly lower in C3H mice than in the other two strains.

摘要

雄性C3H、BALB/c和DBA/2小鼠皮下注射单剂量30 μmol氯化镉/千克。大多数C3H小鼠在15小时内死亡，而所有DBA/2小鼠至少存活48小时。注射镉后6小时，组织学检查显示C3H小鼠肝脏出现严重出血、脂肪变性、带状肝细胞坏死和充血，而在其他品系中，即使在注射后48小时，这些表现也很少见。C3H小鼠在6小时时金属硫蛋白（MT）的诱导率明显低于其他两个品系。