da Silva V A, Ribeiro M J, Masur J
Dev Psychobiol. 1980 Nov;13(6):653-60. doi: 10.1002/dev.420130612.
Ethanol solution (10 or 20% v/v) sweetened with .4% saccharin was given to female rats as the only source of fluid. In the 1st experiment the administration was throughout the gestation period. Developmental, behavioral, and pharmacological tests were performed with the offspring. Litters born from females of the experimental group showed a decrease in the mortality rate induced by pentylenetetrazol, in comparison with either pair-fed controls or an ad libitum control group. No other differences were detected. In the 2nd experiment the administration was throughout the lactation period. Pups raised by lactating mothers receiving ethanol showed a significant decrease in weight gain. Also, the maternal behavior of the ethanol-treated mothers, measured by nest-building and retrieval activities, showed a significant decrease when compared to pair-fed controls.
用0.4%糖精增甜的乙醇溶液（10%或20% v/v）作为唯一的液体来源给予雌性大鼠。在第一个实验中，给药贯穿整个妊娠期。对后代进行发育、行为和药理学测试。与配对喂养对照组或自由采食对照组相比，实验组雌性大鼠所生的窝仔显示由戊四氮诱导的死亡率降低。未检测到其他差异。在第二个实验中，给药贯穿整个哺乳期。由接受乙醇的哺乳期母亲抚养的幼崽体重增加显著减少。此外，通过筑巢和找回活动测量，与配对喂养对照组相比，接受乙醇处理的母亲的母性行为显著减少。
