肝病患者白细胞锌含量降低。
Reduced leucocyte zinc in liver disease.
作者信息
Keeling P W, Jones R B, Hilton P J, Thompson R P
出版信息
Gut. 1980 Jul;21(7):561-4. doi: 10.1136/gut.21.7.561.
Abstract
The zinc content of peripheral blood leucocytes has been measured in normal controls and in three groups of patients with liver disease. A significant reduction in leucocyte zinc, but not erythrocyte zinc, was observed in patients with primary biliary cirrhosis, alcoholic cirrhosis, and active chronic hepatitis. It is suggested that the nucleated tissues of some patients with liver disease are therefore zinc deficient, and that leucocyte zinc may prove of value in the assessment of the zinc status of such patients.
摘要
已对正常对照组以及三组肝病患者外周血白细胞的锌含量进行了测定。在原发性胆汁性肝硬化、酒精性肝硬化和活动性慢性肝炎患者中，观察到白细胞锌含量显著降低，但红细胞锌含量未降低。因此表明，一些肝病患者的有核组织存在锌缺乏，并且白细胞锌可能在评估此类患者的锌状态方面具有价值。
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本文引用的文献
1
ZINC METABOLISM AND CHRONIC ALCOHOLISM.
Am J Clin Nutr. 1965 Aug;17:57-63. doi: 10.1093/ajcn/17.2.57.
2
Zinc in human blood cells: normal values and abnormalities associated with liver disease.
J Clin Invest. 1960 Nov;39(11):1651-6. doi: 10.1172/JCI104188.
3
Zinc metabolism in hepatic dysfunction. II. Correlation of metabolic patterns with biochemical findings.
N Engl J Med. 1957 Nov 28;257(22):1055-65. doi: 10.1056/NEJM195711282572201.
4
Determination of zinc in biological fluids by atomic absorption spectrophotometry in normal and cirrhotic subjects.
J Lab Clin Med. 1965 Sep;66(3):508-16.
5
Intracellular concentrations of water and of the principal electrolytes determined by analysis of isolated human leucocytes.
Clin Sci. 1969 Aug;37(1):205-19.
6
Zinc and collagen content of cirrhotic liver.
Am J Dig Dis. 1970 Sep;15(9):797-802. doi: 10.1007/BF02236039.
7
Binding of zinc to amino acids and serum proteins in vitro.
J Lab Clin Med. 1970 Sep;76(3):416-25.
8
The role of zinc in bone metabolism.
Clin Orthop Relat Res. 1974(103):212-34. doi: 10.1097/00003086-197409000-00084.
9
Experimental zinc deficiency in humans.
Ann Intern Med. 1978 Oct;89(4):483-90. doi: 10.7326/0003-4819-89-4-483.
10
Changes in the electrolyte content of leucocytes at different clinical stages of cirrhosis.
Gut. 1978 Jul;19(7):650-4. doi: 10.1136/gut.19.7.650.
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