2,3-二腈基-1,4-二硫杂-9,10-蒽醌对耻垢分枝杆菌的作用
Effect of 2,3-dinitrilo-1,4-dithia-9,10-anthraquinone on Mycobacterium smegmatis.
作者信息
Drobnica L, Majtán V, Sturdík E, Miko M
出版信息
Folia Microbiol (Praha). 1980;25(5):403-11. doi: 10.1007/BF02876693.
2,3-Dinitrilo-1,4-dithia-9,10-anthraquinone (DDA) is an effective inhibitor of respiration of intact cells of Mycobacterium smegmatis in the presence of glucose, glycerol, pyruvate, acetate and other citric acid cycle intermediates or substrates associated with this cyclic (glutamate, asparagine). DDA inhibits the incorporation of both 14C-leucine and 14C-adenine into appropriate macromolecules of M. smegmatis (TCA-precipitable fractions), and causes a drop in the incorporated activity of U-14C-glycine or its degradation products in all the cell fractions studied (lipids, RNA, DNA, proteins). DDA suppresses the growth of M. smegmatis probably through an interference with the cell energy-carbon metabolism.
2,3-二腈基-1,4-二硫杂-9,10-蒽醌（DDA）是耻垢分枝杆菌完整细胞呼吸的有效抑制剂，其作用条件为存在葡萄糖、甘油、丙酮酸、乙酸盐以及其他柠檬酸循环中间体或与该循环相关的底物（谷氨酸、天冬酰胺）。DDA抑制14C-亮氨酸和14C-腺嘌呤掺入耻垢分枝杆菌的相应大分子（三羧酸循环沉淀级分），并导致在所有研究的细胞级分（脂质、RNA、DNA、蛋白质）中，U-14C-甘氨酸或其降解产物的掺入活性下降。DDA可能通过干扰细胞能量-碳代谢来抑制耻垢分枝杆菌的生长。
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