Rhodes J M, Lind I
Immunology. 1980 Sep;41(1):75-82.
Normal rabbit serum formed soluble complexes with protein A(pA) which were not taken up or broken down by rabbit peritoneal exudate (PE) cells. On the other hand, normal guinea-pig and mouse sera formed precipitating complexes with pA which were rapidly degraded by the appropriate PE cells. Rabbit, guinea-pig and mouse antisera towards staphylococcal pA formed precipitating complexes with pA, all of which were rapidly ingested and degraded by the homologous PE cells. Soluble and precipitated IgG complexes were identified by zone electrophoresis in agar with subsequent autoradiography. Precipitating complexes were formed when 125I-HSA was added to homologous rabbit, guinea-pig and mouse antisera, and these complexes were rapidly ingested and degraded by the corresponding PE cells. Thus, staphylococcal pA-IgG complexes (Fc-bound material) are ingested and degraded to the same extent as similar antigen-antibody complexes (Fab-bound material).
正常兔血清与蛋白A（pA）形成可溶性复合物，兔腹腔渗出液（PE）细胞不会摄取或分解这些复合物。另一方面，正常豚鼠和小鼠血清与pA形成沉淀复合物，这些复合物会被相应的PE细胞迅速降解。兔、豚鼠和小鼠针对葡萄球菌pA的抗血清与pA形成沉淀复合物，所有这些复合物都会被同源的PE细胞迅速摄取并降解。通过琼脂中的区带电泳及随后的放射自显影鉴定可溶性和沉淀性IgG复合物。当将125I-人血清白蛋白（HSA）添加到同源的兔、豚鼠和小鼠抗血清中时会形成沉淀复合物，并且这些复合物会被相应的PE细胞迅速摄取并降解。因此，葡萄球菌pA-IgG复合物（Fc结合物质）与类似的抗原-抗体复合物（Fab结合物质）一样被摄取和降解。
