Prinz W, Bloch J, Gilich G, Mitchell G
Int J Vitam Nutr Res. 1980;50(3):294-300.
We have investigated the humoral immune response to Sheep Red Blood Cells (S.R.B.C.--a T-dependent cellular antigen) in two groups of random-bred guinea pigs. A control group of animals was maintained on "minimal" ascorbate intake, while the test group animals received supplementary vitamin C in their drinking water. Serum haemolytic antibody levels were monitored at various intervals subsequent to immunization with S.R.B.C. The primary antibody response of the ascorbate-supplemented animals differed statistically significantly from that of the controls in two respects. The peak antibody titre was both higher and occurred earlier in the test animals. No significant difference in the antibody response to a secondary injection of antigen was manifest. Our observations suggest that vitamin C stimulates the elaboration of Ig M-type antibodies in particular.
我们研究了两组随机繁殖的豚鼠对绵羊红细胞（S.R.B.C.——一种T细胞依赖性细胞抗原）的体液免疫反应。一组对照动物维持“最低限度”的抗坏血酸摄入量，而试验组动物在饮用水中补充维生素C。在用S.R.B.C.免疫后的不同时间间隔监测血清溶血抗体水平。补充抗坏血酸的动物的初次抗体反应在两个方面与对照组有统计学显著差异。试验组动物的抗体滴度峰值更高且出现更早。二次注射抗原后的抗体反应没有显著差异。我们的观察结果表明，维生素C尤其能刺激Ig M型抗体的产生。
