Isolation of an intermediate of 2-deoxystreptamine biosynthesis from a mutant of Bacillus circulans.
作者信息
Fujiwara T, Takahashi Y, Matsumoto K, Kondo E
出版信息
J Antibiot (Tokyo). 1980 Aug;33(8):824-9. doi: 10.7164/antibiotics.33.824.
PMID:7429985
Abstract
Eight 2-deoxystreptamine-negative (DOS-) mutants were isolated from various strains of Bacillus circulans, normally producing butirosin, xylostasin and ribostamycin. These mutants were classified into two groups (converter and secretor) by the simple method of cosynthesis using agar plate culture. One of the cosynthetic pairs, strain S-11, an intermediate of DOS biosynthesis, S-11-P, was isolated. This compound was converted to butirosin (BTN) effectively by strain 236. The structure of S-11-P was considered to be (1 L or 1 D)-1,3,5/2,4-5-amino-cyclohexanetetrol, and the pathway of DOS biosynthesis is discussed here.
摘要
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