Millett J A, Chin Y, Bitensky L, Chayen J, Husain O
J Clin Pathol. 1980 Jul;33(7):684-7. doi: 10.1136/jcp.33.7.684.
Lysosomal naphthylamidase activity has been measured microdensitometrically in cells in samples obtained by cervical and vaginal irrigation from 22 cases cytologically graded I and II, 28 graded III (moderate to severe dysplasia), 22 graded IV (carcinoma in situ), and 15 cases (grade V) of invasive carcinoma. There was a statistically significant difference in this activity in the cells from cases of grade V as against those in the relatively normal samples (grades I and II; p < 0.001) and as against those of grade IV (p < 0.005). The method is sufficiently robust for routine use provided that it is recognised that elevated activities can be found as a consequence of other factors such as previous surgical intervention and infection with herpes simplex.
通过对22例细胞学分级为I级和II级、28例分级为III级（中度至重度发育异常）、22例分级为IV级（原位癌）以及15例V级浸润癌患者的宫颈和阴道冲洗样本中的细胞进行微密度测定，测量了溶酶体萘基酰胺酶活性。V级病例的细胞中该活性与相对正常样本（I级和II级；p < 0.001）以及IV级病例的细胞中该活性相比，存在统计学上的显著差异（p < 0.005）。只要认识到其他因素（如先前的手术干预和单纯疱疹感染）可能导致活性升高，该方法就足够稳健可用于常规检测。
