Kushner I, Ribich W N, Blair J B
J Lab Clin Med. 1980 Dec;96(6):1037-45.
We studied the synthesis of CRP by perfused livers that had been isolated and removed from 15 rabbits at varying intervals after tissue injury. In each instance CRP was synthesized at constant rates, for 3 to 8 hr, without need for further stimulus. Rates of CRP synthesis by perfused livers rose with increasing duration of tissue injury prior to isolation of the livers and correlated strongly with serum CRP levels attained by the time of sacrifice. The observation that CRP is synthesized by perfused livers at constant rates indicates that the continuing increase in rate of CRP synthesis that occurs in rabbits in vivo appears to depend on continuing exposure to factors of extrahepatic origin and that the consequences of exposure to such factors do not persist isolated of the organ.
我们研究了从15只兔子身上分离并取出的灌注肝脏在组织损伤后不同时间间隔内CRP的合成情况。在每种情况下，CRP均以恒定速率合成3至8小时，无需进一步刺激。灌注肝脏中CRP的合成速率随着肝脏分离前组织损伤持续时间的增加而升高，并且与处死时达到的血清CRP水平密切相关。灌注肝脏以恒定速率合成CRP这一观察结果表明，兔子体内CRP合成速率的持续增加似乎取决于持续暴露于肝外来源的因素，并且暴露于这些因素的后果并非独立于该器官而持续存在。
