癌症与非恶性疾病中血清淀粉样蛋白A和C反应蛋白浓度的比较
Comparison of serum amyloid A protein and C-reactive protein concentrations in cancer and non-malignant disease.
作者信息
Raynes J G, Cooper E H
出版信息
J Clin Pathol. 1983 Jul;36(7):798-803. doi: 10.1136/jcp.36.7.798.
Abstract
Serum amyloid A (SAA) concentrations correlate well with C-reactive protein (CRP) concentrations. However, SAA is sometimes raised in disease when CRP is normal. This appears to occur more often in certain diseases such as rheumatoid arthritis, primary biliary cirrhosis and chronic active hepatitis. SAA concentrations did not distinguish between cancer with and without metastases as previously indicated, although mean concentrations were higher in more advanced tumours. Despite the higher sensitivity of SAA over CRP in the inflammatory response, SAA has little advantage over CRP in the assessment of malignant disease.
摘要
血清淀粉样蛋白A（SAA）浓度与C反应蛋白（CRP）浓度密切相关。然而，在某些疾病中，当CRP正常时SAA有时也会升高。这种情况似乎在类风湿性关节炎、原发性胆汁性肝硬化和慢性活动性肝炎等某些疾病中更常出现。如前所述，SAA浓度无法区分有无转移的癌症，尽管在更晚期的肿瘤中平均浓度更高。尽管在炎症反应中SAA比CRP具有更高的敏感性，但在评估恶性疾病方面SAA比CRP几乎没有优势。
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