Yezersky M, Shechter I, Kariv N, Langer O
J Lab Clin Med. 1980 Dec;96(6):965-73.
The effects of addition of the polystyrene resin XAD-2 to the diet of rabbits on serum cholesterol, on hepatic enzyme of cholesterol synthesis (HMG-CoA reductase), and on atherogenesis was determined. Feeding of XAD-2 caused substantial decrease of total serum cholesterol and of the cholesterol of the apo B-containing lipoproteins (50%). Atherogenesis, which was induced by mechanical injury to the arterial wall, greatly decreased (p < 0.01) in animals fed with 10% XAD-2 supplement in their diet. Average lesions volume of 4.2 +/- 2.0 mm3 per aorta was observed in animals maintained on XAD-2 diet, in comparison to 15.42 +/- 3.3 mm3 in animals maintained on regular diet. The animals maintained on XAD-2 showed elevated activity of hepatic HMG-CoA reductase. The activity of this enzyme was 3.2 fold that obtained from livers of control animals.
研究了给兔子的饮食中添加聚苯乙烯树脂XAD - 2对血清胆固醇、胆固醇合成的肝酶（HMG - CoA还原酶）以及动脉粥样硬化形成的影响。喂食XAD - 2导致血清总胆固醇和含载脂蛋白B的脂蛋白胆固醇大幅降低（50%）。由动脉壁机械损伤诱导的动脉粥样硬化形成，在饮食中添加10% XAD - 2的动物中大幅降低（p < 0.01）。食用XAD - 2饮食的动物，主动脉平均病变体积为4.2±2.0立方毫米，而食用常规饮食的动物为15.42±3.3立方毫米。食用XAD - 2的动物肝脏HMG - CoA还原酶活性升高。该酶的活性是对照动物肝脏的3.2倍。
