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通过局部应用硝酸银治疗变应性和血管运动性鼻炎。

Treatment of allergic and vasomotor rhinitis by the local application of silver nitrate.

作者信息

Bhargava K B, Abhyankar U S, Shah T M

出版信息

J Laryngol Otol. 1980 Sep;94(9):1025-36. doi: 10.1017/s0022215100089817.

Abstract

A new, simple and effective local treatment of allergic and vasomotor rhinitis is presented. Using 15 per cent silver nitrate, bilateral chemical cautery of the anterior part of the nasal septum and inferior turbinates has been carried out at weekly intervals on 1 to 5 occasions, in 41 cases. No distinction was made between allergic rhinitis and vasomotor rhinitis. 92.6 per cent of cases belonged to the age group of 11 to 50 years. There was a slight predominance of female over male patients in this study. Only those cases were selected who had sneezing as the presenting symptom, while 17 per cent of these patients also suffered from asthma. The eosinophil count in the blood was below 5 per cent in 73.2 per cent of cases, and was above 10 per cent in 9.8 per cent of cases. Eosinophils were present in the nasal secretions of of 66.6 per cent of patients. Intestinal parasites were detected in the stools of 19.5 per cent of cases. No significant quantity of methaemoglobin was detected in the blood of any patient. Silver nitrate was applied after topical anaesthesia with 4 per cent lignocaine solution. The majority of patients had 2 to 4 applications. 68.3 per cent of patients had good relief, particularly from sneezing and watering of the nose. If patients treated with only a single application of silver nitrate are excluded from the series, 79.4 per cent patients reported relief. Significantly, out of 7 cases who were suffering from allergic rhinitis as well as asthma, 57.1 per cent of cases had freedom from the asthma. Among 3 patients who had no relief with earlier intranasal hydrocortisone injections, 66.6 per cent cases had good relief with silver nitrate. One patient who had good relief from allergic rhinitis developed anosmia after this treatment and some patients experienced transient sneezing and rhinorrhoea after the application of silver nitrate. Long-term results are awaited and it is suggested that further studies are necessary regarding the number of applications, the interval between applications, the strength of the silver nitrate solution, and the possible use of other chemical or physical agents for this mode of treatment.

摘要

本文介绍了一种新的、简单有效的变应性和血管运动性鼻炎局部治疗方法。对41例患者,使用15%的硝酸银,每周对鼻中隔前部和下鼻甲进行双侧化学烧灼,共进行1至5次。变应性鼻炎和血管运动性鼻炎未作区分。92.6%的病例年龄在11至50岁之间。本研究中女性患者略多于男性。仅选择以打喷嚏为主要症状的病例,其中17%的患者还患有哮喘。73.2%的病例血液嗜酸性粒细胞计数低于5%,9.8%的病例高于10%。66.6%的患者鼻分泌物中有嗜酸性粒细胞。19.5%的病例粪便中检测到肠道寄生虫。所有患者血液中均未检测到大量高铁血红蛋白。用4%利多卡因溶液局部麻醉后应用硝酸银。大多数患者进行了2至4次治疗。68.3%的患者症状得到明显缓解,尤其是打喷嚏和流涕症状。如果将仅接受一次硝酸银治疗的患者排除在该系列之外,79.4%的患者报告症状缓解。值得注意的是,在7例同时患有变应性鼻炎和哮喘的患者中,57.1%的病例哮喘症状消失。在3例早期鼻内注射氢化可的松无效的患者中,66.6%的病例使用硝酸银后症状得到明显缓解。1例变应性鼻炎症状明显缓解的患者在该治疗后出现嗅觉丧失,部分患者在应用硝酸银后出现短暂的打喷嚏和鼻溢液。目前正在等待长期结果,建议对治疗次数、治疗间隔、硝酸银溶液浓度以及该治疗方式可能使用的其他化学或物理制剂进行进一步研究。

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