Mode A, Eneroth P, Gustafsson J A, Hökfelt T, Skett P
J Endocrinol. 1980 Jul;86(1):69-77. doi: 10.1677/joe.0.0860069.
The metabolism of 4-[4-14C]androstene-3,17-dione in the microsomal fraction of livers from male and female rats was investigated after hypothalamic deafferentation at two levels. It was found that frontal deafferentation at the retrochiasmatic level caused a complete 'feminization' of hepatic steroid metabolism in the male rat but was without effect in the female animal. Transection rostral to the suprachiasmatic nuclei was without effect in both sexes. A complete transition from male to female hepatic steroid metabolism after retrochiasmatic deafferentation was reached on day 4 after the operation and persisted for at least 10 weeks. The present results, taken together with previous investigations, indicate that the release of a 'feminizing' factor from the pituitary gland of the male rat is inhibited by a factor produced in, or transported through, the periventricular anterior hypothalamic region including the suprachiasmatic area. No effect on the hepatic steroid metabolism was observed after binding of the rats suggesting that a diurnal rhythm is not essential to this control mechanism.
研究了在下丘脑两个水平去传入神经后，雄性和雌性大鼠肝脏微粒体部分中4-[4-¹⁴C]雄烯二酮-3,17-二酮的代谢情况。结果发现，在视交叉后水平进行额叶去传入神经手术会导致雄性大鼠肝脏类固醇代谢完全“女性化”，但对雌性动物没有影响。在视交叉上核前方横断对两性均无影响。视交叉后去传入神经手术后第4天，雄性大鼠肝脏类固醇代谢从雄性完全转变为雌性，并持续至少10周。目前的结果与先前的研究一起表明，雄性大鼠垂体释放的“女性化”因子受到包括视交叉上区在内的室周前下丘脑区域产生或运输的一种因子的抑制。束缚大鼠后未观察到对肝脏类固醇代谢的影响，这表明昼夜节律对这种控制机制不是必需的。
