Smith E, Williams K L
J Embryol Exp Morphol. 1980 Jun;57:233-40.
Reciprocal transplants were performed between slugs of two strains of Dictyostelium discoideum. Slugs of one strain (NP84 'slugger') showed prolonged migration, while slugs of the other strain (AX3 'fruiter') migrated for a short period only. The transplant experiments showed that the 'slug/fruit' characteristic is tip dependent, since an NP84 tip induced an AX3 rear to migrate for a prolonged period, while an AX3 tip induced the rear of a NP84 slug to fruit without migration. These findings are not consistent with the hypothesis that tips of all stages release only one signal which is interpreted differently by the rest of the cells in the aggregate at different stages. Rather, we propose that the tip of a D. discoideum aggregate may release a number of signals, one of which is stage dependent, and triggers the 'slug/fruit' switch.
在两种盘基网柄菌菌株的蛞蝓之间进行了相互移植实验。其中一个菌株（NP84“蛞蝓型”）的蛞蝓表现出延长的迁移，而另一个菌株（AX3“子实体型”）的蛞蝓仅迁移较短时间。移植实验表明，“蛞蝓/子实体”特征取决于尖端，因为NP84尖端会诱导AX3后端延长迁移，而AX3尖端会诱导NP84蛞蝓的后端形成子实体而不迁移。这些发现与所有阶段的尖端仅释放一种信号的假设不一致，该信号在不同阶段被聚集物中的其他细胞以不同方式解读。相反，我们提出盘基网柄菌聚集物的尖端可能会释放多种信号，其中一种信号取决于阶段，并触发“蛞蝓/子实体”转换。
