Utne H E, Winkler K
Scand J Gastroenterol. 1980;15(3):297-304. doi: 10.3109/00365528009181473.
In eight patients with cirrhosis of the liver the hepatic and the extrahepatic ethanol elimination rate (EER) were studied by steady-state infusion during hepatic venous catheterization. EER measured by single injection overestimated total body EER by 15%. Hepatic and extrahepatic EER were significantly decreased to about two thirds in cirrhosis and were correlated to other variables indicating the severity of the disease. Differences in EER, however, diminish considerably when corrected for body weight, for reasons that are poorly understood. A maximal value of intrahepatic shunted blood could be calculated to 15% (3-38%) of hepatic blood flow. It was correlated to the transsinusoidal pressure gradient (r = 0.91). A rough estimate of the apparent Michaelis constant (Km) of hepatic and extrahepatic EER was in the range of 0.1--0.3 mmol x 1(-1). Forty percent of ethanol elimination occurred outside the liver. The large extrahepatic EER may be important in the development of extrahepatic organ injuries.
在8例肝硬化患者中，通过肝静脉插管稳态输注研究了肝脏和肝外乙醇清除率（EER）。单次注射测量的EER高估了全身EER 15%。肝硬化时肝脏和肝外EER显著降低至约三分之二，并与指示疾病严重程度的其他变量相关。然而，校正体重后，EER的差异显著减小，原因尚不清楚。肝内分流血液的最大值可计算为肝血流量的15%（3%-38%）。它与跨窦压力梯度相关（r = 0.91）。肝脏和肝外EER的表观米氏常数（Km）的粗略估计值在0.1--0.3 mmol x 1(-1)范围内。40%的乙醇清除发生在肝脏外。较大的肝外EER可能在肝外器官损伤的发生中起重要作用。
