阿托品对人体十二指肠酸化后促胰液素释放及吸出的碳酸氢盐分泌的影响。

The effect of atropine on secretin release and aspirated bicarbonate secretion after duodenal acidification in man.

作者信息

Hanssen L E

出版信息

Scand J Gastroenterol. 1980;15(4):465-9. doi: 10.3109/00365528009181502.

Abstract

The effect of duodenal instillation of hydrochloric acid on peripheral plasma immunoreactive secretin (IRS) concentration--without or with a constant intravenous infusion of atropine--was studied in eight healthy volunteers. Without atropine infusion, IRS increased from 1.2 +/- 0.3 pmol/l to a peak value of 17.1 +/- 4.4 pmol/l. The volume of duodenal aspirates increased from 0.74 +/- 0.12 ml/min to 5.03 +/- 0.46 ml/min, and the bicarbonate output from 7.6 +/- 1.7 mumol/min to 349 +/- 39 mumol/min. With atropine infusion (bolus of 500 micrograms + 750 micrograms/h of atropine sulphate), IRS increased from 1.4 +/- 0.3 pmol/l to 14.8 +/- 3.6 pmol/l. The volume of the duodenal aspirates increased from 0.71 +/- 0.08 ml/min to 2.76 +/- 0.37 ml/min and the bicarbonate output from 4.0 +/- 1.6 mumol/min to 142 +/- 33 mumol/min. The integrated IRS response to acidification was 18% lower during atropine infusion (p < 0.05). Both the aspirated flow rate from the duodenum and the bicarbonate output were markedly reduced by atropine infusion, 45% and 59%, respectively (p < 0.005).

摘要

在8名健康志愿者中研究了十二指肠滴注盐酸对外周血浆免疫反应性促胰液素（IRS）浓度的影响——分别在不使用或持续静脉输注阿托品的情况下。在不输注阿托品时，IRS从1.2±0.3 pmol/l增加到峰值17.1±4.4 pmol/l。十二指肠抽吸液量从0.74±0.12 ml/min增加到5.03±0.46 ml/min，碳酸氢盐排出量从7.6±1.7 μmol/min增加到349±39 μmol/min。在输注阿托品（500微克推注+750微克/小时硫酸阿托品）时，IRS从1.4±0.3 pmol/l增加到14.8±3.6 pmol/l。十二指肠抽吸液量从0.71±0.08 ml/min增加到2.76±0.37 ml/min，碳酸氢盐排出量从4.0±1.6 μmol/min增加到142±33 μmol/min。在输注阿托品期间，IRS对酸化的综合反应降低了18%（p<0.05）。输注阿托品使十二指肠抽吸流速和碳酸氢盐排出量均显著降低，分别降低了45%和59%（p<0.005）。