人对外源性促胰液素的血浆促胰液素及胰腺碳酸氢盐反应
Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man.
作者信息
HACKI W H, Bloom S R, Mitznegg P, Domschke W, Domschke S, Belohlavek D, Demling L, Wünsch E
出版信息
Gut. 1977 Mar;18(3):191-5. doi: 10.1136/gut.18.3.191.
Abstract
The dose response of duodenal bicarbonate production during synthetic porcine secretin infusions was studied in six healthy volunteers and related to plasma secretin immunoreactivity. Secretin was infused in each individual at four different doses from 0-1 to 2-7 CU/kg/h, each infusion lasting for 60 minutes. Mean maximal bicarbonate secretion was 33 +/- 4 mEq/h. The secretin plasma level for half maximal bicarbonate response was estimated to be 22 pmol/l. As this level is reported to be achieved by intraduodenal acidification in man, it is concluded that secretin may well play a part in the control of duodenal pH.
摘要
在六名健康志愿者中研究了合成猪促胰液素输注期间十二指肠碳酸氢盐产生的剂量反应，并将其与血浆促胰液素免疫反应性相关联。向每个个体以0.1至2.7 CU/kg/h的四种不同剂量输注促胰液素，每次输注持续60分钟。平均最大碳酸氢盐分泌量为33±4 mEq/h。估计碳酸氢盐反应达到半数最大值时的促胰液素血浆水平为22 pmol/l。由于据报道在人体中十二指肠内酸化可达到这一水平，因此得出结论，促胰液素很可能在十二指肠pH值的控制中发挥作用。
相似文献
1
Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man.人对外源性促胰液素的血浆促胰液素及胰腺碳酸氢盐反应
Gut. 1977 Mar;18(3):191-5. doi: 10.1136/gut.18.3.191.
2
Physiological significance of secretin in the pancreatic bicarbonate secretion. II. Pancreatic bicarbonate response to a physiological increase in plasma secretin concentration.促胰液素在胰腺碳酸氢盐分泌中的生理意义。II. 胰腺碳酸氢盐对血浆促胰液素浓度生理性升高的反应
Scand J Gastroenterol. 1979;14(1):85-90. doi: 10.3109/00365527909179850.
3
Importance of gastrin-releasing peptide on acid-induced secretin release and pancreaticobiliary and duodenal bicarbonate secretion.胃泌素释放肽对酸诱导的促胰液素释放以及胰胆管和十二指肠碳酸氢盐分泌的重要性。
Scand J Gastroenterol. 1996 Oct;31(10):993-1000. doi: 10.3109/00365529609003119.
4
Effect of low dose secretin and caerulein on pure pancreatic bicarbonate secretion and plasma secretin in man.低剂量促胰液素和雨蛙肽对人体纯胰碳酸氢盐分泌及血浆促胰液素的影响。
Acta Hepatogastroenterol (Stuttg). 1979 Dec;26(6):478-81.
5
Pancreatic, hepatic, and duodenal mucosal bicarbonate secretion during infusion of secretin and cholecystokinin. Evidence of the importance of hepatic bicarbonate in the neutralization of acid in the duodenum of anaesthetized pigs.在输注促胰液素和胆囊收缩素期间胰腺、肝脏和十二指肠黏膜的碳酸氢盐分泌。肝脏碳酸氢盐在麻醉猪十二指肠酸中和中重要性的证据。
Scand J Gastroenterol. 1991 Oct;26(10):1035-41. doi: 10.3109/00365529109003953.
6
Effect of secretin on plasma motilin in man.促胰液素对人体血浆胃动素的影响。
Gut. 1977 Jun;18(6):468-71. doi: 10.1136/gut.18.6.468.
7
Inhibition of secretin release and pancreatic bicarbonate secretion by somatostatin infusion in man.在人体中通过输注生长抑素抑制促胰液素释放和胰腺碳酸氢盐分泌。
Scand J Gastroenterol. 1977;12(4):391-4. doi: 10.3109/00365527709181678.
8
The effect of duodenal acidification on plasma secretin and gastrin and pancreatic bicarbonate secretion in man.十二指肠酸化对人体血浆促胰液素、胃泌素及胰腺碳酸氢盐分泌的影响。
Acta Hepatogastroenterol (Stuttg). 1979 Apr;26(2):142-7.
9
Duodenal mucosal bicarbonate secretion in pigs is accompanied by compensatory changes in pancreatic and biliary HCO3- secretion.猪十二指肠黏膜碳酸氢盐分泌伴随着胰腺和胆汁中HCO3-分泌的代偿性变化。
Scand J Gastroenterol. 1994 Oct;29(10):889-96. doi: 10.3109/00365529409094859.
10
The effect of atropine on secretin release and aspirated bicarbonate secretion after duodenal acidification in man.阿托品对人体十二指肠酸化后促胰液素释放及吸出的碳酸氢盐分泌的影响。
Scand J Gastroenterol. 1980;15(4):465-9. doi: 10.3109/00365528009181502.
引用本文的文献
1
Separation of the gut hormone endocrine-cell storage granules of human jejunum using analytical subcellular fractionation.利用分析性亚细胞分级分离法分离人空肠的肠激素内分泌细胞储存颗粒。
Gut. 1980 Mar;21(3):177-80. doi: 10.1136/gut.21.3.177.
2
A re-examination of circulating gastrin and secretin levels in the human newborn.对人类新生儿循环胃泌素和促胰液素水平的重新检测。
Ir J Med Sci. 1981 Feb;150(2):33-7. doi: 10.1007/BF02938192.
3
Patterns of acid-induced release endogenous immunoreactive secretin in children with cystic fibrosis and recurrent pain.囊性纤维化和复发性疼痛患儿中酸诱导内源性免疫反应性促胰液素释放的模式
Ir J Med Sci. 1981 Mar;150(3):66-8. doi: 10.1007/BF02938201.
4
Development of gut hormone responses to feeding in neonates.新生儿肠道激素对进食的反应发育
Arch Dis Child. 1980 Sep;55(9):678-82. doi: 10.1136/adc.55.9.678.
5
Action of secretin on pancreatic enzyme secretion in man. Studies on pure pancreatic juice.促胰液素对人胰腺酶分泌的作用。纯胰液的研究。
Gut. 1984 Aug;25(8):867-73. doi: 10.1136/gut.25.8.867.
6
Effect of secretin and glucagon on Brunner's gland secretion in the rat.促胰液素和胰高血糖素对大鼠十二指肠腺分泌的影响。
Gut. 1984 Mar;25(3):264-8. doi: 10.1136/gut.25.3.264.
7
The plasma concentrations of secretin and vasoactive intestinal polypeptide (VIP) after long-term, strenuous exercise.长期剧烈运动后促胰液素和血管活性肠肽（VIP）的血浆浓度。
Eur J Appl Physiol Occup Physiol. 1983;52(1):5-8. doi: 10.1007/BF00429017.
8
Measurement of gut hormonal peptides in biopsies from human stomach and proximal small intestine.人胃和近端小肠活检组织中肠道激素肽的测量。
Gut. 1983 Feb;24(2):114-9. doi: 10.1136/gut.24.2.114.
9
Radioimmunoassay of secretin. A critical review and current status.促胰液素的放射免疫测定。批判性综述与现状
Dig Dis Sci. 1980 Jul;25(7):529-52. doi: 10.1007/BF01315215.
10
Effects of exogenous secretin on pancreatic and biliary ductal and sphincteric pressures in man demonstrated by endoscopic manometry and correlation with plasma secretin levels.通过内镜测压法显示外源性促胰液素对人体胰胆管及括约肌压力的影响及其与血浆促胰液素水平的相关性。
Dig Dis Sci. 1985 Oct;30(10):909-17. doi: 10.1007/BF01308289.
本文引用的文献
1
Response to secretin in man.人类对促胰液素的反应。
Gastroenterology. 1968 Feb;54(2):197-209.
2
Pancreatic dose-response curves to intravenous secretin in man.人体对静脉注射促胰液素的胰腺剂量反应曲线。
Gastroenterology. 1970 Jun;58(6):828-32.
3
The effect of pure natural secretin on the bicarbonate secretion into the duodenum in man.纯天然促胰液素对人体十二指肠碳酸氢盐分泌的影响。
Scand J Gastroenterol. 1970;5(2):105-11.
4
A comparison of the response to secretin, pancreozymin and a combination of these hormones, in man.人体对促胰液素、胰酶泌素以及这两种激素联合使用的反应比较。
Scand J Gastroenterol. 1969;4(5):411-7.
5
[The synthesis of secretin. VI. Purification of synthetic secretin].[促胰液素的合成。VI. 合成促胰液素的纯化]
Chem Ber. 1972;105(8):2515-22. doi: 10.1002/cber.19721050811.
6
Immunofluorescent localization of secretin and enteroglucagon in human intestinal mucosa.促胰液素和肠高血糖素在人肠黏膜中的免疫荧光定位
Scand J Gastroenterol. 1971;6(8):739-44. doi: 10.3109/00365527109179946.
7
Comparison of synthetic and natural porcine secretins on human pancreatic secretion.合成猪促胰液素与天然猪促胰液素对人体胰腺分泌的比较。
Gastroenterology. 1974 Feb;66(2):204-9.
8
The pancreatic exocrine secretion in duodenal ulcer patients before and after selective proximal vagotomy of the stomach.十二指肠溃疡患者胃选择性近端迷走神经切断术前、后的胰腺外分泌情况。
Scand J Gastroenterol. 1974;9(5):431-6.
9
Reproducibility of the response to secretin and secretin plus pancreozymin in man.人对促胰液素及促胰液素加胰酶泌素反应的可重复性。
Scand J Gastroenterol. 1974;9(4):377-81.
10
Comparison of endogenous release of secretin and cholecystokinin in proximal and distal duodenum in the dog.犬十二指肠近端和远端促胰液素与缩胆囊素内源性释放的比较。
Scand J Gastroenterol. 1974;9(2):153-7.
Zotero 插件