Caldara R, Ferrari C, Barbieri C, Romussi M
Scand J Gastroenterol. 1980;15(4):481-4. doi: 10.3109/00365528009181504.
The effect of 1 week of oral treatment with four antidopaminergic drugs--metoclopramide, sulpiride, haloperidol, and pimozide--on fasting and meal-stimulated serum gastrin levels has been evaluated in healthy subjects. All of the four drugs significantly reduced the gastrin response to a meal, whereas basal concentration was unaffected. It is suggested that this action is mediated by central nervous system dopamine receptor blockade, which might act either via nervous or humoral mechanisms to inhibit gastrin release.
在健康受试者中评估了四种抗多巴胺能药物（甲氧氯普胺、舒必利、氟哌啶醇和匹莫齐特）口服治疗1周对空腹及进食刺激后血清胃泌素水平的影响。这四种药物均显著降低了进食后胃泌素反应，而基础浓度未受影响。提示该作用是由中枢神经系统多巴胺受体阻断介导的，其可能通过神经或体液机制抑制胃泌素释放。
