多潘立酮对胃泌素释放无作用：该药物外周活性的证据。
Lack of effect of domperidone on gastrin release: evidence for a peripheral activity of the drug.
作者信息
Masci E, Caldara R, Testoni P A, Guslandi M, Cambielli M, Passaretti S, Tittobello A
出版信息
Br J Clin Pharmacol. 1984 May;17(5):588-90. doi: 10.1111/j.1365-2125.1984.tb02395.x.
Abstract
The effect of intravenous administration of domperidone, a dopamine receptor antagonist with peripheral activity, on basal and submaximal pentagastrin-stimulated gastric acid secretion and gastrin release has been evaluated in healthy volunteers. No significant changes were observed in the parameters studied. The lack of effect on gastrin release appears to confirm that domperidone is unable to penetrate the blood brain barrier in appreciable amounts in adults.
摘要
在健康志愿者中评估了静脉注射多潘立酮（一种具有外周活性的多巴胺受体拮抗剂）对基础和次最大剂量五肽胃泌素刺激的胃酸分泌及胃泌素释放的影响。在所研究的参数中未观察到显著变化。对胃泌素释放缺乏影响似乎证实了多潘立酮在成人中无法以可观的量穿透血脑屏障。
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