多巴胺输注对人体胃和胰腺分泌以及胃泌素释放的影响。
Effect of dopamine infusion on gastric and pancreatic secretion and on gastrin release in man.
作者信息
Caldara R, Ferrari C, Romussi M, Bierti L, Gandini S, Curtarelli G
出版信息
Gut. 1978 Aug;19(8):724-8. doi: 10.1136/gut.19.8.724.
Abstract
The effect of dopamine infusion on basal and pentagastrin-stimulated gastric secretion, on basal and secretin-CCK-PZ-stimulated pancreatic secretion, and on basal and meal-induced gastrin release has been evaluated in healthy volunteers. Both basal and stimulated gastric acid secretion were significantly inhibited during dopamine infusion with a significant rebound to pre-infusion values after discontinuing dopamine. These effects were prevented by pretreatment with the antidopaminergic drug, metoclopramide. A slight but now significant decrease in amylase and bicarbonate outputs was also observed during dopamine infusion, while gastrin release did not change. These data suggest the existence of dopaminergic mechanisms in the regulation of gastric acid secretion in man.
摘要
在健康志愿者中评估了多巴胺输注对基础和五肽胃泌素刺激的胃酸分泌、对基础和促胰液素-胆囊收缩素-胰酶泌素刺激的胰腺分泌以及对基础和进食诱导的胃泌素释放的影响。在多巴胺输注期间，基础和刺激的胃酸分泌均受到显著抑制，停用多巴胺后出现显著反弹至输注前值。这些作用可通过抗多巴胺能药物甲氧氯普胺预处理来预防。在多巴胺输注期间还观察到淀粉酶和碳酸氢盐输出略有但不显著的下降，而胃泌素释放未改变。这些数据表明人体胃酸分泌调节中存在多巴胺能机制。
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