Viljanen M K, Nieminen S
Scand J Infect Dis. 1980;12(3):211-3. doi: 10.3109/inf.1980.12.issue-3.08.
A systematic vaccination program including tetanus vaccinations was started in Finland in 1957. It covers the children up to school age very effectively. Antibodies of IgG class against tetanus toxoid were quantified by enzyme-linked immunosorbent assay (ELISA) in random samples from 240 Finnish adults. A protective concentration of antibodies (greater than or equal to 0.01 U/ml) was detected in 98.4% of 18--25-year-olds, in 93.3% of 26--35-year-olds, in 68.8% of 36--45-year-olds and in 83.6% of people over 46 years. In people over 36 years almost one half had antitoxin levels below 0.05 U/ml, which some authors suggest is the lowest level that protects against the disease. There were no significant differences in the mean antitoxin titers between men and women.
1957年芬兰启动了一项包括破伤风疫苗接种在内的系统性疫苗接种计划。该计划非常有效地覆盖了学龄儿童。通过酶联免疫吸附测定（ELISA）对240名芬兰成年人的随机样本中抗破伤风类毒素的IgG类抗体进行了定量。在18至25岁的人群中，98.4%检测到保护性抗体浓度（大于或等于0.01 U/ml）；26至35岁的人群中，这一比例为93.3%；36至45岁的人群中为68.8%；46岁以上人群中为83.6%。在36岁以上的人群中，近一半人的抗毒素水平低于0.05 U/ml，一些作者认为这是预防该疾病的最低水平。男性和女性的平均抗毒素滴度没有显著差异。
