White B C, Lincoln C A, Pearce N W, Reeb R, Vaida C
Science. 1980 Sep 26;209(4464):1547-8. doi: 10.1126/science.7433978.
Regular consumers of caffeine had higher muscle tension after three or more hours of abstinence than low caffeine consumers. This difference was absent after double-blind administration of caffeine citrate or placebo. In a discriminative reaction time test, caffeine treatment improved performance. Among subjects receiving placebo, anxiety was highly correlated with prior caffeine use, suggesting that even a brief abstinence may produce anxiety in the regular user.
咖啡因的经常使用者在戒断三小时或更长时间后，肌肉紧张程度高于低咖啡因使用者。在双盲给予柠檬酸咖啡因或安慰剂后，这种差异消失。在一项辨别反应时间测试中，咖啡因治疗改善了表现。在接受安慰剂的受试者中，焦虑与之前的咖啡因使用高度相关，这表明即使短暂戒断也可能使经常使用者产生焦虑。
