Kogelnik H D, Reinartz G, Szepesi T, Seitz W, Wurst F, Mamoli B, Wessely P, Stark H
Strahlentherapie. 1980 Nov;156(11):758-64.
In this pilot study daily low doses of misonidazole (in the range of 1 to 2 g) up to cumulative doses between 7 and 19 g/m2 were used. Serum levels were analysed at different times after administration and according to several dose regimens. We related the cumulative doses to the incidence and severity of the observed peripheral neuropathies. The aim was to find an effective daily low-dose schedule of misonidazole with a clinically acceptable incidence of side effects. Some impressive clinical responses were observed.
在这项初步研究中，使用了每日低剂量的米索硝唑（剂量范围为1至2克），累积剂量达7至19克/平方米。在给药后的不同时间，根据几种给药方案分析血清水平。我们将累积剂量与观察到的周围神经病变的发生率和严重程度相关联。目的是找到一种有效的米索硝唑每日低剂量给药方案，其副作用的临床发生率可接受。观察到了一些令人印象深刻的临床反应。
