Kogelnik H D, Meyer J H, Jentzsch K, Szepesi T, Kärcher K H, Maida E, Mamoli B, Wessely P, Zaunbauer F
Br J Cancer Suppl. 1978 Jun;3:281-5.
Since April 1976 we have performed clinical investigations with multiple doses of the hypoxic cell radiosensitizer misonidazole in 21 patients. A significant side effect of the drug was the development of peripheral sensory neuropathies in 13 patients (8 mild, 5 severe) and of a transient acute organic psychosyndrome in 2 of the 5 patients with a severe polyneuropathy. The severity of the polyneuropathies is related to the total dose of misonidazole and the overall time of drug administration. Treatment schedules designed to obtain the desired sensitizing effect without neurological side effects are under investigation.
自1976年4月以来，我们对21例患者使用多剂量的低氧细胞放射增敏剂米索硝唑进行了临床研究。该药物的一个显著副作用是13例患者（8例轻度，5例重度）出现周围感觉神经病变，在5例患有严重多发性神经病变的患者中，有2例出现短暂的急性器质性精神综合征。多发性神经病变的严重程度与米索硝唑的总剂量和给药的总时间有关。旨在获得所需增敏效果而无神经副作用的治疗方案正在研究中。
