Castro O
Transfusion. 1980 Nov-Dec;20(6):695-703. doi: 10.1046/j.1537-2995.1980.20681057159.x.
Functional and metabolic characteristics of fresh and three-week stored erythrocytes from patients with sickle cell anemia were compared. The storage-related changes in ATP, 2,3-DPG, and P50 in sickle erythrocytes were similar to those in control (HbA) red blood cells. After storage in CPD, sickle erythrocytes maintained significantly higher levels of 2,3-DPG (mean 2.20 +/- 0.73 mM/ml RBC) than did control cells (mean 0.36 +/- 0.13 mM/ml RBC). The posttransfusion recovery and survival of stored SS erythrocytes in autologous recipients and in an animal test system were at least as good as those before storage. Tolerance of the storage lesion by sickle erythrocytes is probably related to their young mean cell age. These results also suggest that the option of autotransfusion should be explored for selected patients with sickle cell disease in special clinical settings.
比较了镰状细胞贫血患者新鲜和储存三周的红细胞的功能和代谢特征。镰状红细胞中与储存相关的ATP、2,3-二磷酸甘油酸（2,3-DPG）和P50的变化与对照（HbA）红细胞中的相似。在CPD中储存后，镰状红细胞维持的2,3-DPG水平（平均2.20±0.73 mM/ml红细胞）显著高于对照细胞（平均0.36±0.13 mM/ml红细胞）。储存的SS红细胞在自体受者和动物试验系统中的输血后恢复和存活至少与储存前一样好。镰状红细胞对储存损伤的耐受性可能与其平均细胞年龄较小有关。这些结果还表明，对于特殊临床环境中选定的镰状细胞病患者，应探索自体输血的选择。
