Bogomolova N N, Boriskin Iu S, Bektemirova M S, Ianova N N, Matevosian K Sh
Vopr Virusol. 1980 May-Jun(3):315-8.
Properties of rabies virus (RV) persisting in chronically infected cultures (CIC): HEp-2--RV and BHK-RV were studied. RV from the HEp-2-RV system retained its pathogenicity for mice for more than 3 years of observation. RV from the BHK-RV system lost this property after 50 passages in CIC. Both RV variants from CIC formed plaques in CER cells, showed marked immunogenic activity in mice, had no interferon-inducing activity in BHK-21 cells, and were not temperature-sensitive. Electron microscopic examinations of CIC culture fluids showed virions of bullet-like, oval, or spherical shapes.
持续存在于慢性感染培养物（CIC）中的狂犬病病毒（RV）特性：对HEp-2-RV和BHK-RV进行了研究。在长达3年多的观察期内，来自HEp-2-RV系统的RV对小鼠仍保持致病性。来自BHK-RV系统的RV在CIC中传代50次后丧失了这一特性。来自CIC的两种RV变体均能在CER细胞中形成蚀斑，在小鼠中表现出显著的免疫原性活性，在BHK-21细胞中无干扰素诱导活性，且对温度不敏感。对CIC培养液进行电子显微镜检查，发现有子弹状、椭圆形或球形的病毒粒子。
