Bogomolova N N, Boriskin Iu S, Bektemirova M S
Vopr Virusol. 1980 Sep-Oct(5):574-6.
Persistence of rabies virus (RV) was studied in two cell cultures: HEp-2-RV and BHK-RV. The infection was demonstrated in 8% cells of the BHK-RV system and 53% cells of HEp-2-RV system by the method of cloning. The virus-free clones were as sensitive to RV infection as the control cultures. The incubation temperature shifts up to 40 degrees C and down to 34 degrees C did not affect the carrier state. 5-BUDR did not activate the infectious process in the chronically infected cells. The factors possibly responsible for RV persistence in cell cultures are discussed.
在两种细胞培养物（HEp-2-RV和BHK-RV）中研究了狂犬病病毒（RV）的持续性。通过克隆方法在BHK-RV系统的8%细胞和HEp-2-RV系统的53%细胞中证实了感染。无病毒克隆对RV感染的敏感性与对照培养物相同。孵育温度升高至40摄氏度和降低至34摄氏度均不影响携带状态。5-溴脱氧尿苷（5-BUDR）未激活慢性感染细胞中的感染过程。讨论了可能导致RV在细胞培养物中持续存在的因素。
