Olson J G, Bourgeois A L, Fang R C, Coolbaugh J C, Dennis D T
Am J Trop Med Hyg. 1980 Sep;29(5):989-97.
We conducted a prospective randomized double blind study on the effects of doxycycline as a prophylactic antibiotic against scrub typhus. A total of 1,125 military subjects was followed for periods as long as 5 months of exposure in a hyperendemic focus in the Pescadores Islands of Taiwan. Oral 200 mg doses of doxycycline (Vibramycin) or placebo were given once each week throughout the trial. The incidence rate of scrub typhus in the placebo group was 2.5 times greater than that of the group taking doxycycline (P = 0.11). When subjects who failed to comply with scheduled administration of doxycycline were removed from the analysis, the incidence rate of scrub typhus in the control group was five times greater than that in the drug group (P = 0.04). The rates of infection with Rickettsia tsutsugamushi and of sick call reports were the same in experimental and control groups. The drug was well tolerated in pretrial tests and complaints were negligible during the conduct of the trial. Doxycycline appears to be an excellent antibiotic for the prevention of scrub typhus among personnel exposed to high risk of infection with R. tsutsugamushi.
我们进行了一项前瞻性随机双盲研究，以探讨强力霉素作为预防恙虫病的抗生素的效果。在台湾澎湖列岛的一个高度流行地区，对总共1125名军事人员进行了长达5个月的随访。在整个试验过程中，每周口服一次200毫克剂量的强力霉素（多西环素）或安慰剂。安慰剂组的恙虫病发病率是服用强力霉素组的2.5倍（P = 0.11）。当将未按计划服用强力霉素的受试者排除在分析之外时，对照组的恙虫病发病率是药物组的5倍（P = 0.04）。实验组和对照组的恙虫病东方体感染率和就诊报告率相同。该药物在预试验中耐受性良好，在试验过程中不良反应可忽略不计。强力霉素似乎是预防暴露于恙虫病东方体高感染风险的人员感染恙虫病的一种优秀抗生素。
