Coniam S W
Anaesthesia. 1980 Jun;35(6):576-80. doi: 10.1111/j.1365-2044.1980.tb03854.x.
A continuous infusion of alphaxalone (as Althesin) was used to maintain anaesthesia for patients undergoing open heart surgery. Plasma levels of the drug were measured at intervals during the procedure. It was found that alphaxalone was adequatley removed from the circulation, despite a period of cardiopulmonary bypass and hypothermia, and provided suitable anaesthesia for this type of surgery.
持续输注alphaxalone(作为Althesin)用于维持接受心脏直视手术患者的麻醉。在手术过程中间隔测量药物的血浆水平。结果发现,尽管经历了一段时间的体外循环和低温,但alphaxalone仍能充分从循环中清除,并为这类手术提供了合适的麻醉效果。