Bendtsen A, Kruse A, Madsen J B, Astrup J, Rosenørn J, Blatt-Lyon B, Cold G E
Br J Anaesth. 1985 Apr;57(4):369-74. doi: 10.1093/bja/57.4.369.
Ten patients with small supratentorial tumours were studied during craniotomy. Cerebral blood flow (CBF) was measured in the contralateral hemisphere by a modification of the Kety and Schmidt technique using xenon-133 i.v. With an Althesin infusion rate of 0.2 ml kg-1 h-1, CBF was 24.4 +/- 5.4 ml min-1/100 g and CMRO2 1.87 +/- 0.44 ml min-1/100 g at PaCO2 4.1 +/- 0.7 kPa (mean +/- SD). During constant infusion rates of Althesin, steady values of CMRO2 were obtained, while an increase in infusion rate of 150% was associated with an increase in plasma alphaxalone concentration, a decrease in CMRO2 and a tendency of further EEG suppression. However, great inter- and intraindividual variations were present, and correlations between CMRO2, EEG activity and plasma alphaxalone concentration were weak.
对10例幕上小肿瘤患者在开颅手术期间进行了研究。采用改良的Kety和Schmidt技术，通过静脉注射氙-133，对侧半球的脑血流量（CBF）进行了测量。在阿法沙龙输注速率为0.2 ml·kg⁻¹·h⁻¹时，在动脉二氧化碳分压（PaCO₂）为4.1±0.7 kPa（均值±标准差）的情况下，CBF为24.4±5.4 ml·min⁻¹/100 g，脑氧代谢率（CMRO₂）为1.87±0.44 ml·min⁻¹/100 g。在阿法沙龙持续输注速率期间，获得了稳定的CMRO₂值，但输注速率增加150%与血浆阿法诺龙浓度升高、CMRO₂降低以及脑电图进一步抑制的趋势相关。然而，个体间和个体内存在很大差异，CMRO₂、脑电图活动和血浆阿法诺龙浓度之间的相关性较弱。
