Levene A
Ann R Coll Surg Engl. 1980 Sep;62(5):327-34.
In man the epidermis is the final destination for most of the melanocytes which are of neural crest origin, and they migrate to a variety of sites. Dermal melanocytic distribution, conspicuous in some lower animals, has a very restricted normal distribution in man, and of the variety of anomalies which exist the blue naevus is the most frequently encountered. It is comparable to the common melanocytoma of dog and hamster. More widespread dermal melanocytoses are rare, and a unique case in which death from melanoma supervened, recently recorded by the author, is an example of a syndrome the only parallel to which appears to be equine melanotic disease, a disorder of aging, greying horses. It is argued on comparative grounds that the newly described syndrome and equine melanotic disease are examples of a neurochristic disorder involving the cephalad segments and dermal melanocytes.
在人类中，大多数黑素细胞起源于神经嵴，表皮是它们的最终归宿，它们会迁移到多个部位。真皮黑素细胞分布在一些低等动物中很明显，但在人类中正常分布非常有限，在存在的各种异常情况中，蓝痣是最常见的。它类似于狗和仓鼠的常见黑素细胞瘤。更广泛的真皮黑素细胞增多症很少见，作者最近记录的一个独特病例，该病例因黑色素瘤死亡，是一种综合征的例子，与之唯一相似的似乎是马黑素沉着病，一种老年灰马的疾病。基于比较的理由认为，新描述的综合征和马黑素沉着病是涉及头侧节段和真皮黑素细胞的神经嵴疾病的例子。
