Mortensen N J
Ann R Coll Surg Engl. 1980 Nov;62(6):462-9.
Changes in the numbers of G cells and the formation and release of gastrin granules have been studies by means of radioimmunoassay and quantitative electron microscopy. The appearance of G-cell granules was affected by the pH and duration of fixation, and after prolonged fixation immature newly formed granules could be identified. In rats fasting up to 3 days first the release and then in turn the maturation and synthesis of granules were depressed. Ultimately the renewal of G cells was inhibited and their numbers declined. During an acute stimulus only a small proportion of total antral gastrin was released and the appearance of G cells was unaltered. In patients treated with cimetidine for 12 months there was no G-cell hyperplasia despite raised stimulated gastrin levels.
已通过放射免疫分析和定量电子显微镜研究了G细胞数量的变化以及胃泌素颗粒的形成和释放。G细胞颗粒的外观受固定液pH值和固定时间的影响，长时间固定后可识别出未成熟的新形成颗粒。在禁食长达3天的大鼠中，首先颗粒的释放受到抑制，随后成熟和合成也受到抑制。最终，G细胞的更新受到抑制，数量减少。在急性刺激期间，仅释放了一小部分总胃窦胃泌素，G细胞的外观未改变。在接受西咪替丁治疗12个月的患者中，尽管刺激后的胃泌素水平升高，但未出现G细胞增生。
