对L-谷氨酸50-L-酪氨酸50共聚物（GT）的免疫反应：成年胸腺切除的影响及免疫抑制的遗传控制

Immune response to the copolymer of L-glutamic acid50-L-tyrosine50 (GT): effect of adult thymectomy and genetic control of immune suppression.

作者信息

Sommé G, Bach M A, Thèze J

出版信息

Ann Immunol (Paris). 1980 Jul-Aug;131D(1):3-12.

Abstract

The secondary antibody response to GT and GT-MBSA (GT coupled to methylated bovine serum albumin) and the ability to generate specific suppressor cells after GT preimmunization were examined in the auto-immune NZB strain and in normal and adult thymectomized C3H, BALB/c and CBA mice. As previously shown C3H, BALB/c and CBA mouse strains do not mount a secondary anti-GT antibody response after immunization with GT. On the contrary NZB mice where shown to develop a small but significant anti-GT antibody production. All the mice tested produced anti-GT antibodies after immunization with GT-MBSA. Adult thymectomy greatly decreased this anti-GT antibody response in BALB/c, C3H and CBA mice, suggesting the involvement of a short-lived T-cell subpopulation in the development of an optimal anti-GT-MBSA response. Preimmunization with GT suppressed the secondary antibody response to GT-MBSA in CBA and BALB/c mice but not in NZB and C3H mice, although all these strains bear the H-2-linked Is genes. This indicates an additional genetic control on the generation of GT-specific suppressor cells.

摘要

在自身免疫性NZB品系以及正常和成年胸腺切除的C3H、BALB/c和CBA小鼠中，检测了对GT和GT-MBSA（与甲基化牛血清白蛋白偶联的GT）的二次抗体反应以及GT预免疫后产生特异性抑制细胞的能力。如先前所示，C3H、BALB/c和CBA小鼠品系在用GT免疫后不会产生二次抗GT抗体反应。相反，NZB小鼠显示出产生少量但显著的抗GT抗体。所有测试的小鼠在用GT-MBSA免疫后均产生抗GT抗体。成年胸腺切除大大降低了BALB/c、C3H和CBA小鼠的这种抗GT抗体反应，表明一种短命的T细胞亚群参与了最佳抗GT-MBSA反应的发展。用GT预免疫抑制了CBA和BALB/c小鼠对GT-MBSA的二次抗体反应，但在NZB和C3H小鼠中未观察到，尽管所有这些品系都携带H-2连锁的Is基因。这表明对GT特异性抑制细胞的产生存在额外的遗传控制。

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