特异性免疫抑制的遗传控制。I. 在无反应性BALB/c小鼠中，由共聚体L-谷氨酸50-L-酪氨酸50（GT）刺激抑制细胞的实验条件。
Genetic control of specific immune suppression. I. Experimental conditions for the stimulation of suppressor cells by the copolymer L-glutamic acid50-L-tyrosine50 (GT) in nonresponder BALB/c mice.
作者信息
Debré P, Kapp J A, Benacerraf B
出版信息
J Exp Med. 1975 Dec 1;142(6):1436-46. doi: 10.1084/jem.142.6.1436.
Abstract
In the present studies we have confirmed that the random copolymer of L-glutamic acid50-L-tyrosine50 (GT) fails to induce an antibody response in a large number of inbred strains of mice. Nevertheless, GT complexed to methylated bovine serum albumin (MBSA) elicits a GT-specific IgG PFC response in vivo. Furthermore, injection of BALB/c mice with 10 to 100 mug of GT specifically decreases their ability to develop anti-GT PFC responses to a subsequent challenge with GT-MBSA. GT-specific tolerance can be transferred to normal, syngeneic recipients by spleen cells or thymocytes of GT-primed animals. These results indicate that the stimulation of suppressor cells can be observed in nonresponder mice with another synthetic polypeptide besides GAT. Various parameters of GT-specific immunosuppression in BALB/c mice are described. The application of these techniques to the study of the genetic factors controlling the stimulation of specific immune suppression is discussed.
摘要
在目前的研究中，我们已证实，L-谷氨酸50-L-酪氨酸50（GT）的无规共聚物在大量近交系小鼠中不能诱导抗体应答。然而，与甲基化牛血清白蛋白（MBSA）复合的GT在体内可引发GT特异性IgG空斑形成细胞（PFC）应答。此外，给BALB/c小鼠注射10至100μg的GT可特异性降低其对随后用GT-MBSA攻击产生抗GT PFC应答的能力。GT特异性耐受性可通过经GT免疫动物的脾细胞或胸腺细胞转移至正常同基因受体。这些结果表明，除了GAT之外，在无应答小鼠中用另一种合成多肽也可观察到抑制细胞的刺激。本文描述了BALB/c小鼠中GT特异性免疫抑制的各种参数。讨论了将这些技术应用于研究控制特异性免疫抑制刺激的遗传因素。
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Genetic control of specific immune suppression. I. Experimental conditions for the stimulation of suppressor cells by the copolymer L-glutamic acid50-L-tyrosine50 (GT) in nonresponder BALB/c mice.特异性免疫抑制的遗传控制。I. 在无反应性BALB/c小鼠中，由共聚体L-谷氨酸50-L-酪氨酸50（GT）刺激抑制细胞的实验条件。
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本文引用的文献
1
Fractionation of nucleic acids with the methylated albumin column.用甲基化白蛋白柱对核酸进行分级分离。
J Mol Biol. 1962 Mar;4:161-72. doi: 10.1016/s0022-2836(62)80048-5.
2
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs.半抗原-聚-L-赖氨酸缀合物在遗传应答豚鼠中作为完全抗原的行为以及在无应答豚鼠中作为半抗原的行为。
J Exp Med. 1966 May 1;123(5):859-79. doi: 10.1084/jem.123.5.859.
3
Specific immune response genes of the guinea pig. I. Dominant genetic control of immune responsiveness to copolymers of L-glutamic acid and L-alanine and L-glutamic acid and L-tyrosine.豚鼠的特异性免疫反应基因。I. 对L-谷氨酸与L-丙氨酸及L-谷氨酸与L-酪氨酸共聚物免疫反应性的显性遗传控制。
J Exp Med. 1971 Aug 1;134(2):458-70. doi: 10.1084/jem.134.2.458.
4
Immune responses in vitro. 3. Development of primary gamma-M, gamma-G, and gamma-A plaque-forming cell responses in mouse spleen cell cultures stimulated with heterologous erythrocytes.体外免疫反应。3. 用异种红细胞刺激小鼠脾细胞培养物中主要γ-M、γ-G和γ-A斑块形成细胞反应的发展。
J Exp Med. 1971 Aug 1;134(2):395-416. doi: 10.1084/jem.134.2.395.
5
Genetic control of specific immune responses.特异性免疫反应的遗传控制。
Adv Immunol. 1969;11:31-74. doi: 10.1016/s0065-2776(08)60477-0.
6
Genetic control of immune responses in vitro. 3. Tolerogenic properties of the terpolymer L-glutamic acid 60-L-alanine30-L-tyrosine10 (GAT) for spleen cells from nonresponder (H-2s and H-2q) mice.体外免疫反应的遗传控制。3. 三元共聚物L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）对无反应性（H-2s和H-2q）小鼠脾细胞的致耐受性特性。
J Exp Med. 1974 Jul 1;140(1):172-84. doi: 10.1084/jem.140.1.172.
7
8
A cellular basis for genetically controlled immunologic unresponsiveness in mice: tolerance induction in T-cells.小鼠基因控制的免疫无反应性的细胞基础：T细胞中的耐受性诱导。
Proc Natl Acad Sci U S A. 1973 Jan;70(1):250-4. doi: 10.1073/pnas.70.1.250.
9
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10
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