Rothschild B M, Sienknecht C W, Kaplan S B, Spindler J S
Ann Rheum Dis. 1980 Aug;39(4):392-5. doi: 10.1136/ard.39.4.392.
The infrequent occurrence of gout in patients with sickle cell anaemia contrast with the high incidence of hyperuricaemia and impaired renal function. This report records the third case of synovial membrane uric acid deposition and the first case of tophaceous deposits in haemoglobin SS patients. The limitations of a diagnosis of gout on the basis of hyperuricaemia and arthritis are confirmed. Analysis of reported cases suggests the existence of 2 forms of arthritis associated with sickle cell anaemia--noninflammatory and inflammatory. Paradoxically, gout appears to be associated with the former, in which the pathophysiological changes probably prevent or diminish the acute inflammatory response.
镰状细胞贫血患者痛风发病率较低，这与高尿酸血症和肾功能受损的高发病率形成对比。本报告记录了滑膜尿酸沉积的第三例病例以及血红蛋白SS患者中痛风石沉积的首例病例。基于高尿酸血症和关节炎诊断痛风的局限性得到了证实。对报告病例的分析表明，与镰状细胞贫血相关的关节炎有两种形式——非炎症性和炎症性。矛盾的是，痛风似乎与前者有关，其中病理生理变化可能会阻止或减轻急性炎症反应。
