Babiker Awab Omer, Kaddam Lamis AbdelGadir
Department of Physiology, Faculty of Medicine, Alneelain University, P.O. Box: 11121, 12702 Khartoum, Sudan.
BMC Hematol. 2018 Dec 27;18:38. doi: 10.1186/s12878-018-0110-7. eCollection 2018.
Sickle cell disease is a hereditary disorder characterized by haematological anaemia. Several studies assumed that adult sickle patients might develop metabolic syndrome features as hyperglycaemia, hypertension and dyslipidaemia. The aim of this study was to evaluate the metabolic syndrome risk factors among adult Sudanese with sickle cell anemia in the steady state.
A prospective cross sectional study design was conducted among thirty adult patients with sickle cell anemia Hb SS (mean age 23 ± 6.1 years) and thirty healthy individuals matched for age and gender. Waist and hip circumferences were measured by simple tape. Venous blood sample were analysed to detect blood glucose level, uric acid, total cholesterol, triglycerides, low and high-density lipoprotein after 8 h overnight fasting by spectrophotometer. Blood pressure was measured by sphygmomanometer. National Cholesterol Education Program-Adult Treatment Panel III was utilised to define metabolic syndrome. Statistical analysis was performed SPSS software version 23. Continuous data were expressed using mean ± SD. -value of < 0.05 (two-tailed) was used to establish statistical significance. Unpaired independent T- test was used.
No significant difference in mean systolic blood pressure in patients group compared to control ( value = 0.3). Mean value of diastolic blood pressure was significantly low in patients group compared to control (65.4 ± 10. 4 VS72.33 ± 8.27 mmHg, value< 0.001). Fasting triglycerides level was comparable between patients group and control (P value = 0.56). While high-density lipoprotein was significantly lower in sicklers compared to control (30.2 ± 8.2 mg/dL vs 44.71 ± 1.85 mg/dL, value< 0.001). Fasting blood glucose was significantly low in sickle compared to control (92.6 ± 13 mg/dL vs 106.83 ± 25.11 mg/dL P value< 0.001). Uric acid level was not statistically differed in patients group compared to control ( value = 0.5).
There was significant decrease in fasting High-density lipoprotein, diastolic blood pressure, mean arterial pressure and fasting blood glucose among SCA patients compared to control. There was no significant difference in waist circumference, systolic blood pressure, fasting triglycerides and uric acid levels between patients and control groups.
镰状细胞病是一种以血液学贫血为特征的遗传性疾病。多项研究认为，成年镰状细胞病患者可能会出现代谢综合征特征，如高血糖、高血压和血脂异常。本研究的目的是评估处于稳定状态的成年苏丹镰状细胞贫血患者的代谢综合征危险因素。
对30例成年镰状细胞贫血Hb SS患者（平均年龄23±6.1岁）和30例年龄及性别匹配的健康个体进行前瞻性横断面研究设计。用简易卷尺测量腰围和臀围。过夜禁食8小时后，采集静脉血样，用分光光度计分析检测血糖水平、尿酸、总胆固醇、甘油三酯、低密度和高密度脂蛋白。用血压计测量血压。采用美国国家胆固醇教育计划成人治疗小组第三次报告来定义代谢综合征。使用SPSS 23软件进行统计分析。连续数据用均值±标准差表示。P值<0.05（双侧）用于确定统计学显著性。采用非配对独立t检验。
与对照组相比，患者组平均收缩压无显著差异（P值=0.3）。与对照组相比，患者组舒张压平均值显著较低（65.4±10.4 vs 72.33±8.27 mmHg，P值<0.001）。患者组与对照组的空腹甘油三酯水平相当（P值=0.56）。与对照组相比，镰状细胞病患者的高密度脂蛋白显著较低（30.2±8.2 mg/dL vs 44.71±1.85 mg/dL，P值<0.001）。与对照组相比，镰状细胞病患者的空腹血糖显著较低（92.6±13 mg/dL vs 106.83±25.11 mg/dL，P值<0.001）。与对照组相比，患者组尿酸水平无统计学差异（P值=0.5）。
与对照组相比，镰状细胞贫血患者的空腹高密度脂蛋白、舒张压、平均动脉压和空腹血糖显著降低。患者组与对照组在腰围、收缩压、空腹甘油三酯和尿酸水平方面无显著差异。
