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本文引用的文献

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MALIGNANT MELANOMAS OF THE SKIN OF THE HEAD AND NECK.
Am J Surg. 1963 Nov;106:852-5. doi: 10.1016/0002-9610(63)90414-8.
2
Melanoma of the head and neck.
Surg Gynecol Obstet. 1963 Jan;116:15-28.
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Clinicopathological correlations in a series of 117 malignant melanomas of the skin of adults.117例成人皮肤恶性黑色素瘤的临床病理相关性研究
Cancer. 1958 Sep-Oct;11(5):1025-43. doi: 10.1002/1097-0142(195809/10)11:5<1025::aid-cncr2820110525>3.0.co;2-3.
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Melanoma of the head and neck. A review of eighty-seven cases.头颈部黑色素瘤。87例病例回顾。
Am J Surg. 1972 Oct;124(4):543-50. doi: 10.1016/0002-9610(72)90083-9.
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Malignant melanoma of the head and neck.头颈部恶性黑色素瘤。
Am J Surg. 1972 Oct;124(4):485-8. doi: 10.1016/0002-9610(72)90072-4.
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Malignant melanoma of the head and neck: a clinicopathological study.头颈部恶性黑色素瘤:一项临床病理研究。
Can J Surg. 1972 Mar;15(2):90-101.
7
Results of regional lymph node dissection for melanoma.黑色素瘤区域淋巴结清扫的结果。
Ann Surg. 1974 Jan;179(1):105-8. doi: 10.1097/00000658-197401000-00020.
8
Melanoma of the head and neck.头颈部黑色素瘤
Ann Surg. 1975 Jul;182(1):86-91. doi: 10.1097/00000658-197507000-00016.
9
Analysis of survival and disease control in stage I melanoma of the head and neck.头颈部I期黑色素瘤的生存与疾病控制分析。
Am J Surg. 1976 Oct;132(4):484-91. doi: 10.1016/0002-9610(76)90325-1.
10
Results of BCG adjuvant immunotherapy for melanoma of the head and neck.卡介苗辅助免疫疗法治疗头颈部黑色素瘤的结果
Am J Surg. 1976 Oct;132(4):476-9. doi: 10.1016/0002-9610(76)90323-8.

头颈部皮肤黑色素瘤的选择性手术治疗

Selective surgical management of cutaneous melanoma of the head and neck.

作者信息

Roses D F, Harris M N, Grunberger I, Gumport S L

出版信息

Ann Surg. 1980 Nov;192(5):629-32. doi: 10.1097/00000658-198011000-00008.

DOI:10.1097/00000658-198011000-00008
PMID:7436592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1344944/
Abstract

A series of 206 patients with cutaneous melanoma of the head and neck has been studied. Ninety patients had a regional lymph node dissections performed. Seventeen lymph node dissections were done therapeutically and 73 were done electively. Thirty-one patients had histologically positive lymph nodes and, of these, 30 patients have been followed to the present time or death. Twenty-nine of these patients (97%) have developed systemic melanoma. Twenty-six patients have died and three are alive with disease. No patient had local recurrence alone while four had local recurrence synchronously with systemic metastases. This contrasts with 29 patients followed for greater than five years with histologically negative nodes, 27 (93.1%) of whom are alive with no evidence of recurrent disease. Regional node metastases with melanoma of the head and neck is an almost certain indication of systemic disease. A selective surgical approach to invasive melanoma in this region is proposed based on the observation in the 31 patients who had radical neck dissections with histologically positive nodes. The metastases always involved the nodal group adjacent to the primary site. This selective approach should allow optimal local control and accurate pathologic staging while limiting the extent of the surgery.

摘要

对206例头颈部皮肤黑色素瘤患者进行了研究。90例患者接受了区域淋巴结清扫术。其中17例淋巴结清扫术为治疗性清扫,73例为选择性清扫。31例患者组织学检查发现淋巴结阳性,其中30例患者随访至今或直至死亡。这些患者中有29例(97%)发生了全身性黑色素瘤。26例患者死亡,3例带瘤生存。没有患者仅出现局部复发,4例患者出现局部复发同时伴有全身转移。这与29例组织学检查淋巴结阴性且随访超过5年的患者形成对比,其中27例(93.1%)存活且无复发疾病迹象。头颈部黑色素瘤出现区域淋巴结转移几乎肯定意味着存在全身性疾病。基于对31例组织学检查淋巴结阳性且接受根治性颈清扫术患者的观察,提出了对该区域侵袭性黑色素瘤的选择性手术方法。转移灶总是累及原发部位附近的淋巴结组。这种选择性方法应能实现最佳的局部控制和准确的病理分期,同时限制手术范围。