Roses D F, Harris M N, Grunberger I, Gumport S L
Ann Surg. 1980 Nov;192(5):629-32. doi: 10.1097/00000658-198011000-00008.
A series of 206 patients with cutaneous melanoma of the head and neck has been studied. Ninety patients had a regional lymph node dissections performed. Seventeen lymph node dissections were done therapeutically and 73 were done electively. Thirty-one patients had histologically positive lymph nodes and, of these, 30 patients have been followed to the present time or death. Twenty-nine of these patients (97%) have developed systemic melanoma. Twenty-six patients have died and three are alive with disease. No patient had local recurrence alone while four had local recurrence synchronously with systemic metastases. This contrasts with 29 patients followed for greater than five years with histologically negative nodes, 27 (93.1%) of whom are alive with no evidence of recurrent disease. Regional node metastases with melanoma of the head and neck is an almost certain indication of systemic disease. A selective surgical approach to invasive melanoma in this region is proposed based on the observation in the 31 patients who had radical neck dissections with histologically positive nodes. The metastases always involved the nodal group adjacent to the primary site. This selective approach should allow optimal local control and accurate pathologic staging while limiting the extent of the surgery.
对206例头颈部皮肤黑色素瘤患者进行了研究。90例患者接受了区域淋巴结清扫术。其中17例淋巴结清扫术为治疗性清扫,73例为选择性清扫。31例患者组织学检查发现淋巴结阳性,其中30例患者随访至今或直至死亡。这些患者中有29例(97%)发生了全身性黑色素瘤。26例患者死亡,3例带瘤生存。没有患者仅出现局部复发,4例患者出现局部复发同时伴有全身转移。这与29例组织学检查淋巴结阴性且随访超过5年的患者形成对比,其中27例(93.1%)存活且无复发疾病迹象。头颈部黑色素瘤出现区域淋巴结转移几乎肯定意味着存在全身性疾病。基于对31例组织学检查淋巴结阳性且接受根治性颈清扫术患者的观察,提出了对该区域侵袭性黑色素瘤的选择性手术方法。转移灶总是累及原发部位附近的淋巴结组。这种选择性方法应能实现最佳的局部控制和准确的病理分期,同时限制手术范围。