Golbs S, Fuchs V, Pfüller U, Ebert E, Pfeifer D
Arch Exp Veterinarmed. 1980;34(3):373-81.
The trace element balance in laboratory rats was found to be affected by somewhat lasting application of "Unitiol". Unambiguous decline of manganese, copper, and zinc concentrations was recorded from blood and liver. Complex fixation of copper was stronger than that of the other elements tested. No dose-dependent changes were observed with the experimental arrangement described. The chromium levels in all examined organs were affected but slightly or not at all. The proposal is made that long-term therapeutic use of chelate formers should be accompanied by properly balanced application of essential trace elements.
实验发现，对实验大鼠持续应用一段时间的“二巯基丙磺酸钠”会影响其微量元素平衡。血液和肝脏中的锰、铜和锌浓度均出现明显下降。铜的络合固定作用强于其他受试元素。在所描述的实验安排中未观察到剂量依赖性变化。所有检查器官中的铬水平虽有影响，但轻微或无影响。建议长期使用螯合剂进行治疗时，应适当平衡必需微量元素的应用。
