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[磺胺甲基嘧啶在家畜体内的药代动力学模型研究。1. 给大型动物静脉注射美巴嗪200后的消除情况]

[Pharmacokinetic model studies of sulfamerazine in domestic mammals. 1. Elimination of Mebacid 200 following intravenous administration to large animals].

作者信息

Losch K, Heinze W, Mieth K, Lender S

出版信息

Arch Exp Veterinarmed. 1980;34(3):443-9.

PMID:7436676
Abstract

Pharmacokinetic data of sulphamerazine were recorded from eight heads each of calf, adult cattle, horse, and sheep, following intravenous application of Mebacid 200, and mathematical implications were discussed. Exponential excretion was recorded from all species, according to the following equation: c = B x e-k2 x t The most favourable pharmacokinetic parameters were recorded from calf.

摘要

在静脉注射200毫克美巴嗪后,记录了犊牛、成年牛、马和绵羊各8头的磺胺甲基嘧啶药代动力学数据,并讨论了其数学意义。所有物种均记录到指数排泄,符合以下方程:c = B × e^(-k2 × t)。犊牛的药代动力学参数最为理想。

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