Losch K, Heinze W, Mieth K
Arch Exp Veterinarmed. 1980;34(4):583-6.
The problem of no residues is elucidated and discussed under pharmacokinetic aspects. An equation with due consideration confidence by which to calculate the absence of residues in drugs is given under the assumption that elimination of such residues should follow the concepts of the monocompartment model. The time is calculated by which all residues of sulphamerazine have disappeared, following application of Mebacid 200 and Mebacid tablets to farm animals.
在药代动力学方面对无残留问题进行了阐释和讨论。在假设此类残留物的消除应遵循单室模型概念的前提下,给出了一个充分考虑置信度的用于计算药物中无残留情况的方程式。计算了在给农场动物施用200毫克美贝酸和含美贝酸片剂后,磺胺间二甲氧嘧啶所有残留物消失所需的时间。