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1
Fatty acids modulation of meal-induced variations in diazepam free fraction.脂肪酸对餐食诱导的地西泮游离分数变化的调节作用。
Br J Clin Pharmacol. 1980 Sep;10(3):308-10. doi: 10.1111/j.1365-2125.1980.tb01763.x.
2
Unchanged protein binding and the increase of serum diazepam levels after food intake.食物摄入后蛋白质结合不变且血清地西泮水平升高。
Acta Pharmacol Toxicol (Copenh). 1977 Feb;40(2):241-6. doi: 10.1111/j.1600-0773.1977.tb02074.x.
3
Diazepam plasma binding in the perinatal period: influence of nonesterified fatty acids.围产期地西泮的血浆蛋白结合：非酯化脂肪酸的影响。
Eur J Clin Pharmacol. 1982;22(2):153-60. doi: 10.1007/BF00542461.
4
Serum protein binding of diazepam and propranolol in the feto-maternal unit from early to late pregnancy.
Br J Obstet Gynaecol. 1986 Apr;93(4):322-8.
5
Differences in in vitro binding of diazepam and N-desmethyldiazepam to maternal and fetal plasma proteins at birth: relation to free fatty acid concentration and other parameters.出生时地西泮和N-去甲基地西泮与母体和胎儿血浆蛋白的体外结合差异：与游离脂肪酸浓度及其他参数的关系
Clin Pharmacol Ther. 1983 Aug;34(2):220-6. doi: 10.1038/clpt.1983.156.
6
Elevated plasma free drug concentrations of propranolol and diazepam during cardiac catheterization.
Circulation. 1980 Nov;62(5):1119-22. doi: 10.1161/01.cir.62.5.1119.
7
Food intake and plasma binding of diazepam.地西泮的食物摄入与血浆结合
Br J Clin Pharmacol. 1977 Feb;4(1):85-6. doi: 10.1111/j.1365-2125.1977.tb00674.x.
8
Drug-plasma protein binding in Kutchin Athapaskan indians.库钦阿萨巴斯卡印第安人的药物与血浆蛋白结合情况
Clin Pharmacol Ther. 1982 Oct;32(4):436-41. doi: 10.1038/clpt.1982.186.
9
Diazepam and lidocaine plasma protein binding in renal disease.肾病中地西泮和利多卡因与血浆蛋白的结合情况
Clin Pharmacol Ther. 1982 Mar;31(3):350-7. doi: 10.1038/clpt.1982.45.
10
Decreased serum protein binding of diazepam and its major metabolite in the neonate during the first postnatal week relate to increased free fatty acid levels.出生后第一周内新生儿地西泮及其主要代谢产物的血清蛋白结合率降低与游离脂肪酸水平升高有关。
Br J Clin Pharmacol. 1984 Jan;17(1):92-8. doi: 10.1111/j.1365-2125.1984.tb05006.x.

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1
First-in-Human Single-Ascending-Dose, Multiple-Dose, and Food Interaction Studies of NRD.E1, an Innovative Nonopioid Therapy for Painful Diabetic Peripheral Neuropathy.用于治疗糖尿病周围神经痛的新型非阿片类药物 NRD.E1 的首次人体单剂量、多剂量和食物相互作用研究。
Clin Pharmacol Drug Dev. 2022 Sep;11(9):1012-1027. doi: 10.1002/cpdd.1103. Epub 2022 Jun 14.
2
Free drug metabolic clearance in elderly people.老年人的游离药物代谢清除率。
Clin Pharmacokinet. 2008;47(5):297-321. doi: 10.2165/00003088-200847050-00002.
3
Total and free serum haloperidol levels in schizophrenic patients and the effect of age thioridazine and fatty acid on haloperidol-serum protein binding in vitro.精神分裂症患者血清中氟哌啶醇的总含量和游离含量以及年龄、硫利达嗪和脂肪酸对氟哌啶醇与血清蛋白体外结合的影响。
Br J Clin Pharmacol. 1981 Apr;11(4):377-82. doi: 10.1111/j.1365-2125.1981.tb01135.x.
4
Pharmacokinetics and bioavailability of intravenous, oral, and rectal nitrazepam in humans.硝西泮在人体中的静脉注射、口服及直肠给药的药代动力学和生物利用度
J Pharmacokinet Biopharm. 1982 Jun;10(3):231-45. doi: 10.1007/BF01059259.
5
Unaltered serum propranolol binding by meal-induced variations in fatty acids.膳食诱导的脂肪酸变化对血清普萘洛尔结合无影响。
Br J Clin Pharmacol. 1982 Apr;13(4):575-6. doi: 10.1111/j.1365-2125.1982.tb01425.x.
6
Interaction of diazepam or lorazepam with alcohol. Psychomotor effects and bioassayed serum levels after single and repeated doses.
Eur J Clin Pharmacol. 1985;28(5):559-65. doi: 10.1007/BF00544067.

本文引用的文献

1
Titration of free fatty acids of plasma: a study of current methods and a new modification.血浆游离脂肪酸的滴定：当前方法研究及一种新改良方法
J Lipid Res. 1960 Apr;1:199-202.
2
Diurnal variations in plasma diazepam concentrations associated with reciprocal changes in free fraction.血浆地西泮浓度的昼夜变化与游离分数的相应变化相关。
Br J Clin Pharmacol. 1980 Mar;9(3):265-72. doi: 10.1111/j.1365-2125.1980.tb04836.x.
3
Diurnal fluctuations in triglyceride, free fatty acids, and insulin during sucrose consumption and insulin infusion in man.人体在摄入蔗糖和输注胰岛素期间甘油三酯、游离脂肪酸及胰岛素的昼夜波动情况。
J Clin Invest. 1971 Mar;50(3):583-91. doi: 10.1172/JCI106528.
4
Diurnal patterns of triglycerides, free fatty acids, blood sugar, and insulin during carbohydrate-induction in man and their modification by nocturnal suppression of lipolysis.人体在碳水化合物诱导期间甘油三酯、游离脂肪酸、血糖和胰岛素的昼夜模式及其通过夜间抑制脂肪分解的改变。
J Clin Invest. 1973 Mar;52(3):732-40. doi: 10.1172/JCI107235.
5
The displacing effect of a fatty acid on the binding of diazepam to human serum albumin.脂肪酸对安定与人类血清白蛋白结合的置换作用。
Biochem Pharmacol. 1975 Jul 15;24(13-14):1361-2. doi: 10.1016/0006-2952(75)90355-x.
6
Food intake and plasma binding of diazepam.地西泮的食物摄入与血浆结合
Br J Clin Pharmacol. 1977 Feb;4(1):85-6. doi: 10.1111/j.1365-2125.1977.tb00674.x.
7
Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat.地西泮在人、狗、兔、豚鼠和大鼠体内的药代动力学及血浆结合情况。
J Pharmacol Exp Ther. 1976 Oct;199(1):67-73.
8
Plasma protein binding of diazepam after a single dose of sodium oleate.单次给予油酸钠后地西泮的血浆蛋白结合情况。
J Pharm Sci. 1978 Jun;67(6):891-2. doi: 10.1002/jps.2600670652.
9
Circular dichroism studies on the inhibiting effect of oleic acid on the binding of diazepam to human serum albumin.油酸对安定与人血清白蛋白结合的抑制作用的圆二色性研究
Biochem Pharmacol. 1977 Nov 15;26(22):2157-61. doi: 10.1016/0006-2952(77)90268-4.
10
Inter- and intrasubject variation in diazepam free fraction.地西泮游离分数的个体间和个体内变异。
Clin Pharmacol Ther. 1979 Aug;26(2):247-55. doi: 10.1002/cpt1979262247.

Fatty acids modulation of meal-induced variations in diazepam free fraction.

作者信息

Naranjo C A, Sellers E M, Khouw V

出版信息

Br J Clin Pharmacol. 1980 Sep;10(3):308-10. doi: 10.1111/j.1365-2125.1980.tb01763.x.

DOI:10.1111/j.1365-2125.1980.tb01763.x
PMID:7437251
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1430077/
Abstract
摘要