精神分裂症患者血清中氟哌啶醇的总含量和游离含量以及年龄、硫利达嗪和脂肪酸对氟哌啶醇与血清蛋白体外结合的影响。
Total and free serum haloperidol levels in schizophrenic patients and the effect of age thioridazine and fatty acid on haloperidol-serum protein binding in vitro.
作者信息
Rowell F J, Hui S M, Fairbairn A F, Eccleston D
出版信息
Br J Clin Pharmacol. 1981 Apr;11(4):377-82. doi: 10.1111/j.1365-2125.1981.tb01135.x.
Abstract
1 Using radioimmunoassays, steady-state levels of total and free haloperidol (obtained by ultrafiltration and dialysis) have been determined in twenty-two patients on long term treatment receiving doses from 3 to 45 mg per day. 2 For the group, both total serum concentration and free drug concentration showed significant correlations (P less than 0.001) with daily dose. 3 No significant correlation was observed between age of the patient and percentage free haloperidol in serum. 4 In vitro experiments using sera from twenty-three healthy volunteers showed significant negative correlations (P less than 0.01) between age and percentage free haloperidol. 5 Thioridazine and oleic acid significantly enhanced the percentage of free haloperidol in normal human sera in vitro.
摘要
- 使用放射免疫分析法，已测定了22例长期接受治疗患者的总氟哌啶醇和游离氟哌啶醇（通过超滤和透析获得）的稳态水平，这些患者每日剂量为3至45毫克。2. 对于该组患者，血清总浓度和游离药物浓度均与每日剂量呈显著相关性（P小于0.001）。3. 未观察到患者年龄与血清中游离氟哌啶醇百分比之间存在显著相关性。4. 使用23名健康志愿者血清进行的体外实验表明，年龄与游离氟哌啶醇百分比之间存在显著负相关（P小于0.01）。5. 硫利达嗪和油酸在体外显著提高了正常人血清中游离氟哌啶醇的百分比。
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