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一名患库欣综合征的女性使用赛庚啶治疗后怀孕两次。病例报告。

Two pregnancies in a woman with Cushing's syndrome treated with cyproheptadine. Case report.

作者信息

Kasperlik-Załuska A, Migdalska B, Hartwig W, Wilczyńska J, Marianowski L, Stopińska-Głuszak U, Lozińska D

出版信息

Br J Obstet Gynaecol. 1980 Dec;87(12):1171-3. doi: 10.1111/j.1471-0528.1980.tb04494.x.

DOI:10.1111/j.1471-0528.1980.tb04494.x
PMID:7437385
Abstract

A young woman with Cushing's syndrome who had had amenorrhoea for six years was treated with cyproheptadine and became pregnant five months later. Treatment with cyproheptadine was continued till six weeks after delivery by which time all the features of Cushing's syndrome had disappeared. The baby developed normally but died of gastroenteritis when four months old. Two years later the patient became pregnant again without further treatment. Pregnancy and labour were uncomplicated and mother and son did well. A full remission of Cushing's syndrome was confirmed two months after delivery.

摘要

一名患有库欣综合征且闭经六年的年轻女性接受了赛庚啶治疗,五个月后怀孕。赛庚啶治疗持续至产后六周,此时库欣综合征的所有症状均已消失。婴儿发育正常,但四个月大时死于肠胃炎。两年后,患者未经进一步治疗再次怀孕。妊娠和分娩过程顺利,母婴情况良好。产后两个月证实库欣综合征完全缓解。

相似文献

1
Two pregnancies in a woman with Cushing's syndrome treated with cyproheptadine. Case report.一名患库欣综合征的女性使用赛庚啶治疗后怀孕两次。病例报告。
Br J Obstet Gynaecol. 1980 Dec;87(12):1171-3. doi: 10.1111/j.1471-0528.1980.tb04494.x.
2
Successful pregnancy after cyproheptadine treatment for Cushing's disease.
Eur J Obstet Gynecol Reprod Biol. 1982 Sep;13(6):343-7. doi: 10.1016/0028-2243(82)90069-7.
3
Cushing's disease presenting with growth failure: clinical remission during cyproheptadine therapy.以生长发育迟缓为表现的库欣病:赛庚啶治疗期间临床缓解
Arch Dis Child. 1979 Jun;54(6):466-8. doi: 10.1136/adc.54.6.466.
4
Cyproheptadine may act at the pituitary in Cushing's disease: evidence from CRF stimulation.赛庚啶可能在库欣病中作用于垂体:来自促肾上腺皮质激素释放因子刺激的证据。
J Endocrinol Invest. 1989 Mar;12(3):197-200. doi: 10.1007/BF03349961.
5
Pregnancy after cyproheptadine treatment for Cushing's disease.
N Engl J Med. 1981 Oct 8;305(15):893-4. doi: 10.1056/NEJM198110083051514.
6
Sodium valproate and cyproheptadine may independently induce a remission in the same patient with Cushing's disease.丙戊酸钠和赛庚啶可能分别使同一例库欣病患者病情缓解。
Acta Endocrinol (Copenh). 1983 Oct;104(2):160-3. doi: 10.1530/acta.0.1040160.
7
Cyproheptadine in the control of Cushing's disease.赛庚啶对库欣病的控制作用
Johns Hopkins Med J. 1981 Aug;149(2):77-83.
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Cyproheptadine treatment in Cushing's disease.赛庚啶治疗库欣病
J Endocrinol Invest. 1996 Apr;19(4):242-7. doi: 10.1007/BF03349875.
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[Use of cyproheptadine in the treatment of Cushing's disease].
Clin Ter. 1979 Feb 28;88(4):345-54.
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Prolonged remission of a case of Cushing's disease following cessation of cyproheptadine therapy.停用赛庚啶治疗后库欣病一例的长期缓解
Acta Endocrinol (Copenh). 1983 Mar;102(3):436-8. doi: 10.1530/acta.0.1020436.

引用本文的文献

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The diagnosis and management of Cushing's syndrome in pregnancy.妊娠合并库欣综合征的诊断与治疗。
J Neuroendocrinol. 2022 Aug;34(8):e13118. doi: 10.1111/jne.13118. Epub 2022 May 1.
2
Use of cabergoline for the management of persistent Cushing's disease in pregnancy.使用卡麦角林治疗妊娠期持续性库欣病。
BMJ Case Rep. 2017 Jul 14;2017:bcr-2016-217855. doi: 10.1136/bcr-2016-217855.
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Cushing's disease and pregnancy.库欣病与妊娠
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