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The effect of prostaglandin E2 microinjected into the rat hypothalamus on urinary excretion of water and sodium.微量注射到大鼠下丘脑的前列腺素E2对水和钠尿排泄的影响。
Br J Pharmacol. 1980 Nov;70(3):415-7. doi: 10.1111/j.1476-5381.1980.tb08718.x.
2
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3
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Ethanol-induced water diuresis is not prostaglandin dependent.乙醇诱导的水利尿并不依赖前列腺素。
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2
Possible roles of prostaglandins in the anteroventral third ventricular region in the hyperosmolality-evoked vasopressin secretion of conscious rats.前列腺素在前腹侧第三脑室区域在清醒大鼠高渗诱导的血管加压素分泌中的可能作用。
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本文引用的文献

1
Central cholinergic and adrenergic mechanisms in the release of antidiuretic hormone.抗利尿激素释放中的中枢胆碱能和肾上腺素能机制。
Br J Pharmacol. 1972 Apr;44(4):617-27. doi: 10.1111/j.1476-5381.1972.tb07301.x.
2
A microinjection study of the control of antidiuretic hormone release by the supraoptic nucleus of the hypothalamus in the cat.猫下丘脑视上核对抗利尿激素释放控制的微量注射研究。
J Physiol. 1974 Sep;241(3):607-28. doi: 10.1113/jphysiol.1974.sp010674.
3
Effects on fluid balance of intraventricular infusions of prostaglandin E(1).脑室内注入前列腺素E(1)对液体平衡的影响。
Acta Physiol Scand. 1975 Feb;93(2):286-8. doi: 10.1111/j.1748-1716.1975.tb05817.x.
4
Vasopressin release during ventriculo-cisternal perfusion with prostaglandin E2 in the dog.犬在脑室-脑池灌注前列腺素E2期间抗利尿激素的释放
J Endocrinol. 1976 Dec;71(3):325-31. doi: 10.1677/joe.0.0710325.
5
Influence of prostaglandin E1 on cerebral mechanisms involved in the control of fluid balance.前列腺素E1对参与体液平衡调节的脑机制的影响。
Acta Physiol Scand. 1976 Sep;98(1):85-93. doi: 10.1111/j.1748-1716.1976.tb10306.x.
6
Antidiuresis of centrally administered amines and peptides and release of antidiuretic hormone from isolated rat neurohypophysis.中枢给予胺类和肽类药物的抗利尿作用以及离体大鼠神经垂体抗利尿激素的释放
Jpn J Pharmacol. 1977 Feb;27(1):153-61. doi: 10.1254/jjp.27.153.
7
Effects of centrally affecting drugs on the diuretic and antidiuretic actions of intracerebroventricular prostaglandin E2.中枢作用药物对脑室内前列腺素E2利尿和抗利尿作用的影响。
Jpn J Pharmacol. 1978 Feb;28(1):49-56. doi: 10.1254/jjp.28.49.
8
Effects of intracerebroventricular prostaglandins E2 and F2alpha on the urine outflow, and a possible role of pgE2 as a modulator.脑室内前列腺素E2和F2α对尿液流出的影响以及前列腺素E2作为调节剂的可能作用。
Jpn J Pharmacol. 1978 Feb;28(1):33-40. doi: 10.1254/jjp.28.33.

微量注射到大鼠下丘脑的前列腺素E2对水和钠尿排泄的影响。

The effect of prostaglandin E2 microinjected into the rat hypothalamus on urinary excretion of water and sodium.

作者信息

Fujimoto S

出版信息

Br J Pharmacol. 1980 Nov;70(3):415-7. doi: 10.1111/j.1476-5381.1980.tb08718.x.

DOI:10.1111/j.1476-5381.1980.tb08718.x
PMID:7437648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044354/
Abstract

1 Effects of prostaglandin E2 (PGE2) microinjected into the supraoptic (SON) and the ventromedial nuclei of the hypothalamus (VMH) on urine outflow were studied in rats anaesthetized with ethanol. 2 PGE2 injected into the SON caused antidiuresis and increased the excretion rate of Na+. These effects of PGE2 were prevented by pretreatment with phentolamine but not propranolol, suggesting that they are mediated by alpha-adrenoceptors in the SON. 3 PGE2 injected into the VMH caused diuresis and increased the excretion rate of Na+. These effects were prevented by pretreatment with propranolol but not phentolamine, suggesting that they are mediated through beta-adrenoceptors in the VMH.

摘要
  1. 研究了向用乙醇麻醉的大鼠视上核（SON）和下丘脑腹内侧核（VMH）微量注射前列腺素E2（PGE2）对尿排出量的影响。2. 向视上核注射PGE2导致抗利尿并增加Na+排泄率。PGE2的这些作用可被酚妥拉明预处理所阻断，但不能被普萘洛尔阻断，提示它们是由视上核中的α-肾上腺素能受体介导的。3. 向下丘脑腹内侧核注射PGE2导致利尿并增加Na+排泄率。这些作用可被普萘洛尔预处理所阻断，但不能被酚妥拉明阻断，提示它们是通过下丘脑腹内侧核中的β-肾上腺素能受体介导的。