微量注射到大鼠下丘脑的前列腺素E2对水和钠尿排泄的影响。
The effect of prostaglandin E2 microinjected into the rat hypothalamus on urinary excretion of water and sodium.
作者信息
Fujimoto S
出版信息
Br J Pharmacol. 1980 Nov;70(3):415-7. doi: 10.1111/j.1476-5381.1980.tb08718.x.
Abstract
1 Effects of prostaglandin E2 (PGE2) microinjected into the supraoptic (SON) and the ventromedial nuclei of the hypothalamus (VMH) on urine outflow were studied in rats anaesthetized with ethanol. 2 PGE2 injected into the SON caused antidiuresis and increased the excretion rate of Na+. These effects of PGE2 were prevented by pretreatment with phentolamine but not propranolol, suggesting that they are mediated by alpha-adrenoceptors in the SON. 3 PGE2 injected into the VMH caused diuresis and increased the excretion rate of Na+. These effects were prevented by pretreatment with propranolol but not phentolamine, suggesting that they are mediated through beta-adrenoceptors in the VMH.
摘要
- 研究了向用乙醇麻醉的大鼠视上核（SON）和下丘脑腹内侧核（VMH）微量注射前列腺素E2（PGE2）对尿排出量的影响。2. 向视上核注射PGE2导致抗利尿并增加Na+排泄率。PGE2的这些作用可被酚妥拉明预处理所阻断，但不能被普萘洛尔阻断，提示它们是由视上核中的α-肾上腺素能受体介导的。3. 向下丘脑腹内侧核注射PGE2导致利尿并增加Na+排泄率。这些作用可被普萘洛尔预处理所阻断，但不能被酚妥拉明阻断，提示它们是通过下丘脑腹内侧核中的β-肾上腺素能受体介导的。
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本文引用的文献
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Br J Pharmacol. 1972 Apr;44(4):617-27. doi: 10.1111/j.1476-5381.1972.tb07301.x.
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A microinjection study of the control of antidiuretic hormone release by the supraoptic nucleus of the hypothalamus in the cat.猫下丘脑视上核对抗利尿激素释放控制的微量注射研究。
J Physiol. 1974 Sep;241(3):607-28. doi: 10.1113/jphysiol.1974.sp010674.
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Effects on fluid balance of intraventricular infusions of prostaglandin E(1).脑室内注入前列腺素E(1)对液体平衡的影响。
Acta Physiol Scand. 1975 Feb;93(2):286-8. doi: 10.1111/j.1748-1716.1975.tb05817.x.
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J Endocrinol. 1976 Dec;71(3):325-31. doi: 10.1677/joe.0.0710325.
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