Wilkinson J M, Hendry J H, Hunter R D
Br J Radiol. 1980 Sep;53(633):890-3. doi: 10.1259/0007-1285-53-633-890.
An investigation has been made into the changes in total dose required as a consequence of proposed increases in dose-rate in low-dose-rate treatments of cancer of the uterine cervix. The relationship between total irradiation time and dose-rate has been measured using an assay based on mouse-tail radionecrosis, with irradiation schedules similar to existing and proposed human cervix treatments. This relationship, which is similar to that observed in other biological systems, predicts that the total dose for epithelial tolerance should be reduced by about one third when the dose-rate is increased from 1.0 to 3.5 Gy per hour. The clinical implications of this finding are discussed.
针对子宫颈癌低剂量率治疗中因提议提高剂量率而导致的所需总剂量变化展开了一项调查。利用基于小鼠尾巴放射性坏死的测定法，采用与现有及提议的人体子宫颈治疗相似的照射方案，测量了总照射时间与剂量率之间的关系。这种关系与在其他生物系统中观察到的相似，预测当剂量率从每小时1.0戈瑞提高到3.5戈瑞时，上皮耐受的总剂量应降低约三分之一。讨论了这一发现的临床意义。
